{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:00:04Z","timestamp":1773392404942,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1077","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To quantify wrist cartilage using contrast MRI and compare with the extent of adjacent synovitis and bone marrow edema (BME) in patients with rheumatoid arthritis (RA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>18 patients with RA underwent post-contrast fat-suppressed T \u00a01weighted coronal imaging. Cartilage area at the centre of the scaphoid-capitate and radius-scaphoid joints was measured by in-house developed software. We defined cartilage as the pixels with signal intensity between two thresholds (lower: 0.4, 0.5 and 0.6 times the muscle signal, upper: 0.9, 1.0, 1.1, 1.2 and 1.3 times the muscle signal). We investigated the association of cartilage loss with synovitis and BME score derived from RA MRI scoring system.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Cartilage area was correlated with BME score when thresholds were adequately set with lower threshold at 0.6 times the muscle signal and upper threshold at 1.2 times the muscle signal for both SC (r \u00a0s=\u22120.469, p &amp;lt; 0.05) and RS (r \u00a0s=\u22120.486, p &amp;lt; 0.05) joints, while it showed no significant correlation with synovitis score at any thresholds.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Our software can accurately quantify cartilage in the wrist and BME associated with cartilage loss in patients with RA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>Our software can quantify cartilage using conventional MR images of the wrist. BME is associated with cartilage loss in RA patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20170167","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T11:27:49Z","timestamp":1500031669000},"source":"Crossref","is-referenced-by-count":6,"title":["Cartilage quantification using contrast-enhanced MRI in the wrist of rheumatoid arthritis: cartilage loss is associated with bone marrow edema"],"prefix":"10.1093","volume":"90","author":[{"given":"Motoshi","family":"Fujimori","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Hokkaido University , Sapporo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Sapporo Yamanoue Hospital , Sapporo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiminori","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Sapporo Yamanoue Hospital , Sapporo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Ikeno","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sapporo Yamanoue Hospital , Sapporo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology, Kurashiki Central Hospital , Kurashiki , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine, Hokkaido University , Sapporo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Kamishima","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Hokkaido University , Sapporo , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,8,21]]},"reference":[{"key":"2024050213465673800_b1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.berh.2012.10.004","article-title":"Should modern imaging be part of remission criteria in rheumatoid arthritis?","volume":"26","author":"Haavardsholm","year":"2012","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2024050213465673800_b2","doi-asserted-by":"crossref","first-page":"R44","DOI":"10.1186\/ar4202","article-title":"Monitoring cartilage loss in the hands and wrists in rheumatoid arthritis with magnetic resonance imaging in a multi-center clinical trial: impress (NCT00425932","volume":"15","author":"Peterfy","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"2024050213465673800_b3","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1002\/1529-0131(200109)44:9<2009::AID-ART349>3.0.CO;2-L","article-title":"The relationship between disease activity, joint destruction, and functional capacity over the course of rheumatoid arthritis","volume":"44","author":"Welsing","year":"2001","journal-title":"Arthritis Rheum"},{"key":"2024050213465673800_b4","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1136\/ard.2010.138693","article-title":"Physical disability in rheumatoid arthritis is associated with cartilage damage rather than bone destruction","volume":"70","author":"Aletaha","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 1","key":"2024050213465673800_b5","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1136\/ard.2004.031773","article-title":"An introduction to the EULAR-OMERACT rheumatoid arthritis MRI reference image atlas","volume":"64","author":"Ostergaard","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"2024050213465673800_b6","first-page":"1158","article-title":"Magnetic resonance imaging in rheumatoid arthritis: summary of OMERACT activities, current status, and plans","volume":"28","author":"Conaghan","year":"2001","journal-title":"J Rheumatol"},{"key":"2024050213465673800_b7","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.joca.2010.06.002","article-title":"Detection of degenerative cartilage disease: comparison of high-resolution morphological MR and quantitative T2 mapping at 3.0 Tesla","volume":"18","author":"Apprich","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"2024050213465673800_b8","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1136\/annrheumdis-2012-202850","article-title":"Osteitis and Synovitis, but not bone erosion, is associated with proteoglycan loss and microstructure damage in the cartilage of patients with rheumatoid arthritis","volume":"73","author":"Herz","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"2024050213465673800_b9","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1186\/ar4462","article-title":"MRI osteitis predicts cartilage damage at the wrist in RA: a three-year prospective 3T MRI study examining cartilage damage","volume":"16","author":"McQueen","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"2024050213465673800_b10","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1136\/ard.2009.127324","article-title":"Assessment of cartilage loss at the wrist in rheumatoid arthritis using a new MRI scoring system","volume":"69","author":"McQueen","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"2024050213465673800_b11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00256-010-0935-z","article-title":"Simplified approach to MR image quantification of the rheumatoid wrist: a pilot study","volume":"40","author":"Kamishima","year":"2011","journal-title":"Skeletal Radiol"},{"key":"2024050213465673800_b12","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"69","author":"Aletaha","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"2024050213465673800_b13","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.3899\/jrheum.090350","article-title":"Reducing invasiveness, duration, and cost of magnetic resonance imaging in rheumatoid arthritis by omitting intravenous contrast injection -- does it change the assessment of inflammatory and destructive joint changes by the OMERACT RAMRIS?","volume":"36","author":"Ostergaard","year":"2009","journal-title":"J Rheumatol"},{"key":"2024050213465673800_b14","first-page":"743","article-title":"How to read radiographs according to the Sharp\/van der Heijde method","volume":"26","author":"van der Heijde","year":"1999","journal-title":"J Rheumatol"},{"issue":"Suppl 1","key":"2024050213465673800_b15","doi-asserted-by":"crossref","first-page":"i23","DOI":"10.1136\/ard.2004.031823","article-title":"The EULAR-OMERACT rheumatoid arthritis MRI reference image atlas: the wrist joint","volume":"64","author":"Ejbjerg","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"2024050213465673800_b16","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20151000","article-title":"Accurate quantitative assessment of synovitis in rheumatoid arthritis using pixel-by-pixel, time-intensity curve shape analysis","volume":"89","author":"Sakashita","year":"2016","journal-title":"Br J Radiol"},{"key":"2024050213465673800_b17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jmri.25371","article-title":"Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T2 mapping at 3T MRI of the wrist: feasibility and clinical application","volume":"45","author":"Rehnitz","year":"2017","journal-title":"J Magn Reson Imaging"},{"key":"2024050213465673800_b18","doi-asserted-by":"crossref","DOI":"10.1002\/jmri.25688","article-title":"Feasibility of gadoteric acid for delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at the wrist and knee and comparison with Gd-DTPA","author":"Rehnitz","year":"2017","journal-title":"J Magn Reson Imaging"},{"key":"2024050213465673800_b19","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/art.33352","article-title":"Molecular imaging of cartilage damage of finger joints in early rheumatoid arthritis with delayed gadolinium-enhanced magnetic resonance imaging","volume":"64","author":"Miese","year":"2012","journal-title":"Arthritis Rheum"},{"key":"2024050213465673800_b20","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/RCT.0000000000000164","article-title":"Comparison of quantitative and semiquantitative dynamic contrast-enhanced MRI with respect to their correlation to delayed gadolinium-enhanced MRI of the cartilage in patients with early rheumatoid arthritis","volume":"39","author":"M\u00fcller-Lutz","year":"2015","journal-title":"J Comput Assist Tomogr"}],"container-title":["The British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/90\/1077\/20170167\/57382434\/bjr.20170167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/90\/1077\/20170167\/57382434\/bjr.20170167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T13:50:58Z","timestamp":1714657858000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/doi\/10.1259\/bjr.20170167\/7445974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,1]]},"references-count":20,"journal-issue":{"issue":"1077","published-online":{"date-parts":[[2017,8,21]]},"published-print":{"date-parts":[[2017,8,1]]}},"URL":"https:\/\/doi.org\/10.1259\/bjr.20170167","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,8,1]]},"published":{"date-parts":[[2017,8,1]]},"article-number":"20170167"}}