{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:01:03Z","timestamp":1790110863810,"version":"4.0.1"},"reference-count":97,"publisher":"Oxford University Press (OUP)","issue":"1085","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:p>In osteoarthritis research, imaging plays an important role in clinical trials and epidemiological observational studies. In this narrative review article, we will describe recent developments in imaging of osteoarthritis in the research arena, mainly focusing on literature evidence published within the past 3 years (2014\u20132017). We will primarily focus on MRI including advanced imaging techniques that are not currently commonly used in routine clinical practice, although radiography, ultrasound and nuclear medicine (radiotracer) imaging will also be discussed. Research efforts to uncover the disease process of OA as well as to discover a disease modifying OA drug continue. MRI continues to play a large role in these endeavors, while compositional MRI techniques will increasingly become important due to their ability to assess \u201cpremorphologic\u201d biochemical changes of articular cartilage and other tissues in and around joints. Radiography remain the primary imaging modality for defining inclusion\/exclusion criteria as well as an outcome measure in OA clinical trials, despite known limitations for visualization of OA features. Compositional MRI techniques show promise for predicting structural and clinical outcomes in OA research. Ultrasound can be a useful adjunct to radiography and MRI particularly for evaluation of hand OA. Newer imaging techniques such as hybrid PET\/MRI may have a potential but require further research and validation.<\/jats:p>","DOI":"10.1259\/bjr.20170349","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T10:41:45Z","timestamp":1513939305000},"source":"Crossref","is-referenced-by-count":51,"title":["Imaging of osteoarthritis\u2014recent research developments and future perspective"],"prefix":"10.1093","volume":"91","author":[{"given":"Daichi","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine , Boston, MA , USA"},{"name":"Department of Radiology, Stony Brook University School of Medicine , Stony Brook, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank W","family":"Roemer","sequence":"additional","affiliation":[{"name":"Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine , Boston, MA , USA"},{"name":"Department of Radiology, University of Erlangen-Nuremberg , Erlangen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Guermazi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,19]]},"reference":[{"key":"2024050214284750200_b1","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1136\/annrheumdis-2016-210815","article-title":"EULAR recommendations for the \u00a0use of imaging in the clinical management \u00a0of peripheral joint osteoarthritis","volume":"76","author":"Sakellariou","year":"2017","journal-title":"\u00a0Ann Rheum Dis"},{"key":"2024050214284750200_b2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.joca.2015.03.012","article-title":"OARSI clinical trials recommendations: 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