{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T04:16:26Z","timestamp":1771992986511,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1084","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To determine whether intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) derived parameters can be associated with tumour stage of oesophageal squamous cell carcinoma (SCC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>60 patients with resectable oesophageal SCC and 20 healthy individuals underwent oesophageal DWI-using multi b-values with a 3.0\u2009T MR system. Pure diffusion coefficient (D), perfusion-related incoherent microcirculation (D*), microvascular volume fraction (f) and apparent diffusion coefficient (ADC) were measured on DWI. Statistical analyses were performed to determine associations of DWI-derived parameters with T-stage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>ADC (r = \u22120.842), D (r = \u22120.729), D* (r = \u22120.301) and f (r = \u22120.817) were negatively correlated with T-stage of oesophageal SCC (all p &amp;lt; 0.01), and the multinominal regression analyses revealed that IVIM-derived parameters including D (p = 0.038; odds ratio &amp;lt;1) and f (p &amp;lt; 0.001; odds ratio &amp;lt;1) were associated with T-stage. The Mann\u2013Whitney U tests with Bonferroni correction showed that D, f and ADC could discriminate oesophageal SCC, especially T \u00a01-staged tumour, from normal oesophagus (all p &amp;lt; 0.05) while D* could not (p &amp;gt; 0.05). By receiver operating characteristic analyses, f could be the best indicator for detecting oesophageal SCC with an area under receiver operating characteristic (AUC) of 0.964, especially T \u00a01-staged cancer with an AUC of 0.984, and for discriminating T \u00a01-stages between T \u00a00\u20131 and T \u00a02 \u00a0\u2013 \u00a03 with an AUC of 0.957, and between T \u00a00 \u00a0\u2013 \u00a02 and T \u00a03 with an AUC of 0.945 in comparison with any other DWI-derived parameter.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>IVIM derived parameters can be associated with T-stage of oesophageal SCC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge<\/jats:title>\n                  <jats:p>(1) IVIM-derived parameters are negatively correlated with stage of oesophageal SCC. (2) Among IVIM-derived parameters, microvascular volume fraction helps detect and stage oesophageal SCC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20170421","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T15:11:55Z","timestamp":1515424315000},"source":"Crossref","is-referenced-by-count":16,"title":["Intravoxel incoherent motion diffusion-weighted imaging of resectable oesophageal squamous cell carcinoma: association with tumour stage"],"prefix":"10.1093","volume":"91","author":[{"given":"Yu-cheng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiology, Sichuan Key Laboratory of Medical Imaging, Affiliated Hospital of North Sichuan Medical College , Nanchong, Sichuan , China"},{"name":"Department of Radiology, Dazhou Central Hospital , Dazhou, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-wu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Key Laboratory of Medical Imaging, Affiliated Hospital of North Sichuan Medical College , Nanchong, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Key Laboratory of Medical Imaging, Affiliated Hospital of North Sichuan Medical College , Nanchong, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan-lin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Key Laboratory of Medical Imaging, Affiliated Hospital of North Sichuan Medical College , Nanchong, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Key Laboratory of Medical Imaging, Affiliated Hospital of North Sichuan Medical College , Nanchong, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-lian","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Key Laboratory of Medical Imaging, Affiliated Hospital of North Sichuan Medical College , Nanchong, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Key Laboratory of Medical Imaging, Affiliated Hospital of North Sichuan Medical College , Nanchong, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Key Laboratory of Medical Imaging, Affiliated Hospital of North Sichuan Medical College , Nanchong, Sichuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"2024050214232767900_b1","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int J Cancer"},{"key":"2024050214232767900_b2","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1053\/j.gastro.2012.08.002","article-title":"Burden of gastrointestinal disease in the United States: 2012 update","volume":"143","author":"Peery","year":"2012","journal-title":"Gastroenterology"},{"key":"2024050214232767900_b3","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3322\/caac.20121","article-title":"Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths","volume":"61","author":"Siegel","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"2024050214232767900_b4","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cgh.2012.03.030","article-title":"Management of high-grade dysplasia and intramucosal adenocarcinoma in barrett\u2019s esophagus","volume":"10","author":"Wani","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2024050214232767900_b5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/00000658-199409000-00012","article-title":"Radical lymph node dissection for cancer of the thoracic esophagus","volume":"220","author":"Akiyama","year":"1994","journal-title":"Ann Surg"},{"key":"2024050214232767900_b6","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/00000658-199211000-00010","article-title":"Surgical strategies in esophageal carcinoma with emphasis on radical lymphadenectomy","volume":"216","author":"Lerut","year":"1992","journal-title":"Ann Surg"},{"key":"2024050214232767900_b7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0022-5223(19)38900-7","article-title":"En bloc resection for neoplasms of the esophagus and cardia","volume":"85","author":"Skinner","year":"1983","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"Spec No A","key":"2024050214232767900_b8","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1102\/1470-7330.2008.9007","article-title":"Staging esophageal cancer","volume":"8","author":"Quint","year":"2008","journal-title":"Cancer Imaging"},{"key":"2024050214232767900_b9","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1148\/radiology.156.3.4023234","article-title":"Esophageal imaging by MR and CT: study of normal anatomy and neoplasms","volume":"156","author":"Quint","year":"1985","journal-title":"Radiology"},{"key":"2024050214232767900_b10","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1148\/radiol.2393042031","article-title":"Diffusion-weighted and perfusion MR imaging for brain tumor characterization and assessment of treatment response","volume":"239","author":"Provenzale","year":"2006","journal-title":"Radiology"},{"key":"2024050214232767900_b11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/jmri.10116","article-title":"In vivo diffusion-weighted MRI of the breast: potential for lesion characterization","volume":"15","author":"Sinha","year":"2002","journal-title":"J Magn Reson Imaging"},{"key":"2024050214232767900_b12","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.2214\/AJR.06.0601","article-title":"Predicting response of colorectal hepatic metastasis: value of pretreatment apparent diffusion coefficients","volume":"188","author":"Koh","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"2024050214232767900_b13","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1148\/radiol.2322030778","article-title":"High-b-value diffusion-weighted MR imaging for pretreatment prediction and early monitoring of tumor response to therapy in mice","volume":"232","author":"Roth","year":"2004","journal-title":"Radiology"},{"key":"2024050214232767900_b14","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1200\/JCO.2003.05.069","article-title":"Early detection of response to radiation therapy in patients with brain malignancies using conventional and high b-value diffusion-weighted magnetic resonance imaging","volume":"21","author":"Mardor","year":"2003","journal-title":"J Clin Oncol"},{"key":"2024050214232767900_b15","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(02)09520-X","article-title":"Diffusion MRI for prediction of response of rectal cancer to chemoradiation","volume":"360","author":"Dzik-Jurasz","year":"2002","journal-title":"Lancet"},{"key":"2024050214232767900_b16","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.2214\/AJR.06.1403","article-title":"Diffusion-weighted MRI in the body: applications and challenges in oncology","volume":"188","author":"Koh","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"2024050214232767900_b17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/RLI.0b013e3181ffc485","article-title":"Comparison of biexponential and monoexponential model of diffusion weighted imaging in evaluation of renal lesions: preliminary experience","volume":"46","author":"Chandarana","year":"2011","journal-title":"Invest Radiol"},{"key":"2024050214232767900_b18","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.mri.2014.05.002","article-title":"Comparison of accuracy of intravoxel incoherent motion and apparent diffusion coefficient techniques for predicting malignancy of head and neck tumors using half-Fourier single-shot turbo spin-echo diffusion-weighted imaging","volume":"32","author":"Sakamoto","year":"2014","journal-title":"Magn Reson Imaging"},{"key":"2024050214232767900_b19","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1148\/radiol.09090891","article-title":"Variability of renal apparent diffusion coefficients: limitations of the monoexponential model for diffusion quantification","volume":"254","author":"Zhang","year":"2010","journal-title":"Radiology"},{"key":"2024050214232767900_b20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1148\/radiology.168.2.3393671","article-title":"Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging","volume":"168","author":"Le Bihan","year":"1988","journal-title":"Radiology"},{"key":"2024050214232767900_b21","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.mri.2014.03.003","article-title":"Using intravoxel incoherent motion (IVIM) MR imaging to predict lipiodol uptake in patients with hepatocellular carcinoma following transcatheter arterial chemoembolization: a preliminary result","volume":"32","author":"Park","year":"2014","journal-title":"Magn Reson Imaging"},{"key":"2024050214232767900_b22","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jmri.22081","article-title":"Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast-enhanced MRI alone and in combination: preliminary experience","volume":"31","author":"Patel","year":"2010","journal-title":"J Magn Reson Imaging"},{"key":"2024050214232767900_b23","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1148\/radiol.2493080080","article-title":"Liver cirrhosis: intravoxel incoherent motion MR imaging-pilot study","volume":"249","author":"Luciani","year":"2008","journal-title":"Radiology"},{"key":"2024050214232767900_b24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/jmri.23607","article-title":"Liver fibrosis: an intravoxel incoherent motion (IVIM) study","volume":"36","author":"Chow","year":"2012","journal-title":"J Magn Reson Imaging"},{"key":"2024050214232767900_b25","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.2214\/AJR.10.5515","article-title":"Intravoxel incoherent motion in body diffusion-weighted MRI: reality and challenges","volume":"196","author":"Koh","year":"2011","journal-title":"AJR Am J Roentgenol"},{"key":"2024050214232767900_b26","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1148\/radiol.14131895","article-title":"Atypical imaging features of primary central nervous system lymphoma that mimics glioblastoma: utility of intravoxel incoherent motion MR imaging","volume":"272","author":"Suh","year":"2014","journal-title":"Radiology"},{"key":"2024050214232767900_b27","first-page":"103","volume-title":"AJCC cancer staging manual","author":"American Joint Committee on Cancer","year":"2010","edition":"7th ed"},{"key":"2024050214232767900_b28","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00330-008-1291-4","article-title":"Diagnostic performance of diffusion-weighted magnetic resonance imaging in esophageal cancer","volume":"19","author":"Sakurada","year":"2009","journal-title":"Eur Radiol"},{"key":"2024050214232767900_b29","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1053\/j.seminoncol.2012.05.010","article-title":"Diagnosis of hepatocellular carcinoma: newer radiological tools","volume":"39","author":"Lee","year":"2012","journal-title":"Semin Oncol"},{"key":"2024050214232767900_b30","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1177\/0284185114559426","article-title":"A comparative study of apparent diffusion coefficient and intravoxel incoherent motion-derived parameters for the characterization of common solid hepatic tumors","volume":"56","author":"Zhu","year":"2015","journal-title":"Acta Radiol"},{"key":"2024050214232767900_b31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"2024050214232767900_b32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A guideline of selecting and reporting intraclass correlation coefficients for reliability research","volume":"15","author":"Koo","year":"2016","journal-title":"J Chiropr Med"},{"key":"2024050214232767900_b33","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1148\/radiol.13122712","article-title":"Intravoxel incoherent motion diffusion-weighted MR imaging for characterization of focal pancreatic lesions","volume":"270","author":"Kang","year":"2014","journal-title":"Radiology"},{"key":"2024050214232767900_b34","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1148\/rg.334135027","article-title":"From the radiologic pathology archives: esophageal neoplasms: radiologic-pathologic correlation","volume":"33","author":"Lewis","year":"2013","journal-title":"Radiographics"},{"key":"2024050214232767900_b35","first-page":"641","article-title":"In vitro experimental study of the relationship between the apparent diffusion coefficient and changes in cellularity and cell morphology","volume":"22","author":"Matsumoto","year":"2009","journal-title":"Oncol Rep"},{"key":"2024050214232767900_b36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1148\/radiology.191.1.8134596","article-title":"Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings","volume":"191","author":"Aronen","year":"1994","journal-title":"Radiology"},{"key":"2024050214232767900_b37","first-page":"4264","article-title":"Tumor angiogenesis and interstitial hypertension","volume":"56","author":"Boucher","year":"1996","journal-title":"Cancer Res"},{"key":"2024050214232767900_b38","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nm0603-685","article-title":"Molecular regulation of vessel maturation","volume":"9","author":"Jain","year":"2003","journal-title":"Nat Med"},{"key":"2024050214232767900_b39","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1007\/s00330-011-2359-0","article-title":"Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis","volume":"22","author":"Aoyagi","year":"2012","journal-title":"Eur Radiol"},{"key":"2024050214232767900_b40","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s00330-012-2604-1","article-title":"Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases","volume":"23","author":"Andreou","year":"2013","journal-title":"Eur Radiol"},{"key":"2024050214232767900_b41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.crad.2008.06.005","article-title":"Quantitative assessment of first-pass perfusion of oesophageal squamous cell carcinoma using 64-section MDCT: initial observation","volume":"64","author":"Chen","year":"2009","journal-title":"Clin Radiol"},{"key":"2024050214232767900_b42","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1102\/1470-7330.2013.0033","article-title":"Does volume perfusion computed tomography enable differentiation of metastatic and non-metastatic mediastinal lymph nodes in lung cancer patients? A feasibility study","volume":"13","author":"Spira","year":"2013","journal-title":"Cancer Imaging"},{"key":"2024050214232767900_b43","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1148\/radiol.13130444","article-title":"Intravoxel incoherent motion diffusion-weighted MR imaging of hepatocellular carcinoma: correlation with enhancement degree and histologic grade","volume":"270","author":"Woo","year":"2014","journal-title":"Radiology"}],"container-title":["The British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/91\/1084\/20170421\/57379987\/bjr.20170421.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/91\/1084\/20170421\/57379987\/bjr.20170421.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T14:29:37Z","timestamp":1714660177000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/doi\/10.1259\/bjr.20170421\/7450825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,5]]},"references-count":43,"journal-issue":{"issue":"1084","published-online":{"date-parts":[[2018,2,5]]},"published-print":{"date-parts":[[2018,4,1]]}},"URL":"https:\/\/doi.org\/10.1259\/bjr.20170421","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,4,1]]},"published":{"date-parts":[[2018,2,5]]},"article-number":"20170421"}}