{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:19:17Z","timestamp":1782307157924,"version":"3.54.5"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1083","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To retrospectively investigate the standardized uptake value (SUV)-related and heterogeneous texture parameters individually and in combination for differentiating between low- and high-risk 18Fluorone-fludeoxyglucose (18F-FDG)-avid thymic epithelial tumours (TETs) with\u00a0positron emission tomography (PET)\/CT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>SUV-related and 6 texture parameters (entropy, homogeneity, dissimilarity, intensity variability, size-zone variability and zone percentage) were compared between 11 low-risk and 23 high-risk TETs (metabolic tumour volume\u00a0&amp;gt;10.0\u2009cm3 and SUV\u00a0\u22652.5). Diagnostic performance was evaluated by receiver operating characteristic analysis. The diagnostic value of combining SUV and texture parameters was examined by a scoring system.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>High-risk TETs were significantly higher in SUVmax (p = 0.022), entropy (p = 0.038), intensity variability (p = 0.041) and size-zone variability (p = 0.045) than low-risk TETs. Diagnostic accuracies of these 4 parameters, dissimilarity and zone percentage which also showed significance in receiver operating characteristic analysis ranged between 64.7 and 73.5% without significant differences in AUC (range; 0.71 to 0.75) (p \u2265 0.05\u2009each). Each parameter was scored as 0 (negative for high-risk) or 1 (positive for high-risk) according to each threshold criterion, then scores were summed [0 or 1 for low-risk TETs (median; 1);\u00a0\u22652 for high-risk TETs (median; 4)]. The sensitivity, specificity and accuracy of detecting high-risk TETs were 100, 81.8 and 94.1%, respectively, with an AUC of 0.99.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>The diagnostic performances of individual SUVmax and texture parameters were relatively low. However, combining these parameters can significantly increase diagnostic performance when differentiating between relatively large low- and high-risk 18F-FDG-avid TETs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>Combined use of SUVmax and texture parameters can significantly increase the diagnostic performance when differentiating between low- and high-risk TETs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20170546","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T15:27:26Z","timestamp":1511882846000},"source":"Crossref","is-referenced-by-count":25,"title":["Texture analysis of 18F-FDG PET\/CT for grading thymic epithelial tumours: usefulness of combining SUV and texture parameters"],"prefix":"10.1093","volume":"91","author":[{"given":"Masatoyo","family":"Nakajo","sequence":"first","affiliation":[{"name":"Department of Radiology, Kagoshima University, Graduate School of Medical and Dental Sciences , Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Jinguji","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kagoshima University, Graduate School of Medical and Dental Sciences , Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Shinaji","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of W\u00fcrzburg , W\u00fcrzburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Nakajo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanpuh Hospital , Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kagoshima University, Graduate School of Medical and Dental Sciences , Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Tani","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kagoshima University, Graduate School of Medical and Dental Sciences , Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Kagoshima University, Graduate School of Medical and Dental Sciences , Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yoshiura","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kagoshima University, Graduate School of Medical and Dental 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