{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T16:36:36Z","timestamp":1768408596772,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1084","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>This pilot study determined if the ultrasound texture feature \u201ccontrast\u201d was associated with cardiovascular disease (CVD) risk factors and subclinical arterial disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>We evaluated ultrasound images of the right common carotid artery (CCA) from a convenience sample of 151 participants and examined relationships between contrast, CVD risk factors, carotid intima-media thickness (IMT) and coronary artery calcium (CAC). Grey level difference statistics algorithms were used to evaluate the texture feature \u201ccontrast\u201d from carotid ultrasound images. Right CCA IMT measurements were made in triplicate in the distal 1\u2009cm segment of the far wall of the artery and CAC score was measured using the Agatston scoring method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>In individual models that included age, sex and race, grey level difference statistics contrast (outcome) was associated independently with age [beta (standard error) = \u20130.87 (0.38) per year; p = 0.02], C-reactive protein [\u20132.22 (0.96) per mg dl\u20131; p = 0.02], high-density lipoprotein cholesterol [0.61 (0.24) per mg dl\u20131; p = 0.01] and CCA IMT [\u20130.06 (0.02) microns; p = 0.001]. Other CVD risk factors and CAC were not associated independently with contrast.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>These findings support the potential use of the ultrasound texture contrast for evaluating arterial injury and CVD risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>This paper contributes to the literature in that it describes how the greyscale texture feature \u201ccontrast\u201d is related to CVD risk factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20170637","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T15:13:29Z","timestamp":1515424409000},"source":"Crossref","is-referenced-by-count":23,"title":["Carotid artery ultrasound texture, cardiovascular risk factors, and subclinical arterial disease: the Multi-Ethnic Study of Atherosclerosis (MESA)"],"prefix":"10.1093","volume":"91","author":[{"given":"Carol C","family":"Mitchell","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health , Madison, WI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia E","family":"Korcarz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health , Madison, WI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew C","family":"Tattersall","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health , Madison, WI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam D","family":"Gepner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health , Madison, WI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebekah L","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington , Seattle, WA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy S","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology , Johns Hopkins Hospital , Baltimore, MD , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel D","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Departments of Environmental & Occupational Health Sciences, Medicine, and Epidemiology, University of Washington , Seattle, WA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn L","family":"McClelland","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington , Seattle, WA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health , Madison, WI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"2024050214230415000_b1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10278-011-9417-7","article-title":"Evaluation of texture for classification of abdominal aortic aneurysm after endovascular repair","volume":"25","author":"Garc\u00eda","year":"2012","journal-title":"J Digit 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