{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T17:26:33Z","timestamp":1794072393558,"version":"4.8.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1084","license":[{"start":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T00:00:00Z","timestamp":1515715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>MRI is being used increasingly as a modality that can provide important information about breast cancer. Diffusion-weighted imaging (DWI) is an imaging technique from which\u00a0apparent diffusion coefficient (ADC) values can be calculated in addition to obtaining important structural information which cannot be obtained from other imaging studies. We did not find any significant relationships between ADC values and prognostic factors, but did provide some explanations for conflicting results in the literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>The ADC results of 61\u00a0females with invasive ductal carcinomas were evaluated. DWI was performed and ADC values were calculated from the area in which restriction of diffusion was the highest in ADC mapping. B value was 500 and region of interest (ROI) was designated between 49\u00a0and\u00a0100\u00a0mm2. Calculations were performed automatically by the device. Tissue samples were obtained for prognostic factor evaluation. The relationships between ADC and prognostic factors were investigated. Comparisons between groups were made with one-way ANOVA and Kruskal Wallis test. Pairwise comparisons were made with Dunn\u2019s test. Analyses of categorical variables were made with Chi-square test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>We found a weak negative correlation between ADC and Ki-67 values (r = \u22120.279; p = 0.029). When we compared ADC values in regard to tumour type, we found no significant differences for tumour grade, Ki-67 positivity, estrogen receptor\u00a0positivity, progesterone receptor\u00a0positivity, C-erb B2, lymphovascular invasion and ductal carcinoma in situ or lobular carcinoma in situ\u00a0component. On a side note, we found that mean ADC values decreased as tumour grade increased; however, this was not statistically significant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>The literature contains studies that report conflicting results which may be caused by differences in B values, ROI area and magnetic field strength. Multicentre studies and systematic reviews of these findings may produce crucial data for the use of DWI in breast cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>To determine if any significant relationship exists between DWI findings and prognostic factors of breast cancer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20170705","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T10:51:27Z","timestamp":1515063087000},"source":"Crossref","is-referenced-by-count":30,"title":["Is there any relationship between adc values of diffusion-weighted imaging and the histopathological prognostic factors of invasive ductal carcinoma?"],"prefix":"10.1093","volume":"91","author":[{"given":"Hale","family":"Aydin","sequence":"first","affiliation":[{"name":"Department of Radiology, Dr AY Ankara Oncology Research and Training Hospital , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"Guner","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dr AY Ankara Oncology Research and Training Hospital , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isil","family":"Esen Bostanci","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dr AY Ankara Oncology Research and Training Hospital , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarife\u00a0Melda","family":"Bulut","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr AY Ankara Oncology Research and Training Hospital , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilgin Kadri","family":"Aribas","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dr AY Ankara Oncology Research and Training Hospital , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutfi","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Dr AY Ankara Oncology Research and Training Hospital , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ali","family":"Gulcelik","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Dr AY Ankara Oncology Research and Training Hospital , Ankara , Turkey"},{"name":"4Department of General Surgery, Gulhane Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,12]]},"reference":[{"key":"2024050214251196800_b1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.soc.2014.07.005","article-title":"Emerging modalities in breast cancer imaging","volume":"23","author":"Aminololama-Shakeri","year":"2014","journal-title":"Surg Oncol Clin N 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