{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:06:54Z","timestamp":1760854014289,"version":"3.41.2"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1086","license":[{"start":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:00:00Z","timestamp":1520467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To investigate the impact of low-tube-voltage 90-kVp acquisition combined with advanced modeled iterative reconstruction algorithm (Admire) on radiation exposure, image quality, artifacts, and assessment of stenosis in carotid and intracranial CT\u00a0angiography (CTA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Dual-energy CTA studies of 43 patients performed on a third-generation 192-slice dual-source CT were retrospectively evaluated. Intraindividual comparison of 90-kVp and linearly\u00a0blended 120-kVp equivalent image series (M_0.6, 60% 90-kVp, 40% Sn-150-kVp) was performed. Contrast-to-noise and signal-to-noise ratios of common carotid artery, internal carotid artery, middle cerebral artery, and basilar artery were calculated. Qualitative image analysis included evaluation of artifacts and suitability for angiographical assessment at shoulder level, carotid bifurcation, siphon, and intracranial by three independent radiologists. Detection and quantification of carotid stenosis were performed. Radiation dose was expressed as dose\u2013length\u00a0product (DLP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Contrast-to-noise values of all arteries were significantly increased in 90-kVp compared to M_0.6 (p &amp;lt; 0.001). Suitability for angiographical evaluation was rated excellent with low artifacts for all levels in both image series. Both 90-kVp and M_0.6 showed excellent accordance for detection and grading of carotid stenosis with almost perfect interobserver agreement (carotid stenoses in 32 of 129 segments\u037e intraclass correlation coefficient, 0.94). dose\u2013length\u00a0product was reduced by 40.3% in 90-kVp (110.6 \u00b1 32.1 vs 185.4 \u00b1 47.5 mGy\u00b7cm, p &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>90-kVp carotid and intracranial CTA with Admire provides increased quantitative and similarly good qualitative image quality, while reducing radiation exposure substantially compared to M_0.6. Diagnostic performance for arterial stenosis detection and quantification remained excellent.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>90-kVp carotid and intracranial CTA with an advanced iterative reconstruction algorithm results in excellent image quality and reduction of radiation exposure without limiting diagnostic performance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20170927","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T14:18:05Z","timestamp":1519913885000},"source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic yield of 90-kVp low-tube-voltage carotid and intracerebral CT-angiography: effects on radiation dose, image quality and diagnostic performance for the detection of carotid stenosis"],"prefix":"10.1093","volume":"91","author":[{"given":"Doris","family":"Leithner","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt , Frankfurt , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian L","family":"Wichmann","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt , Frankfurt , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scherwin","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt , Frankfurt , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon S","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt , Frankfurt , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz H","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt , Frankfurt , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J","family":"Vogl","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt , Frankfurt , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Erik","family":"Scholtz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt , Frankfurt , Germany"},{"name":"Division of Radiology, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"key":"2024050214315712400_b1","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1161\/hs1101.098524","article-title":"Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bank","volume":"32","author":"Grau","year":"2001","journal-title":"Stroke"},{"key":"2024050214315712400_b2","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1007\/s00330-015-3623-5","article-title":"Effective dose and organ doses estimation taking tube current modulation into account with a commercial software package","volume":"25","author":"Lopez-Rendon","year":"2015","journal-title":"Eur Radiol"},{"key":"2024050214315712400_b3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s003300050674","article-title":"Dose reduction in CT by on-line tube current control: principles and validation on phantoms and 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