{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:21:44Z","timestamp":1754396504497,"version":"3.41.2"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1086","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>This study used a population-based propensity score (PS)-matched analysis to compare the effectiveness of tomotherapy-based image-guided intensity-modulated radiotherapy (referred to as T-IMRT) with that of linear accelerator based (referred to as L-IMRT) for clinically localized pharyngeal cancer (LPC, divided into nasopharyngeal cancer and non-nasopharyngeal cancer) with definitive concurrent chemoradiotherapy (CCRT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Eligible LPC patients diagnosed between 2007 and 2014 were identified among all citizens in Taiwan from the Health and Welfare Data Science Center database. A PS-matched sample based on the PS estimated from the covariables of interest was constructed to compare the effectiveness of T-IMRT with L-IMRT. In the primary analysis, overall survival (OS) was compared for assessment of effectiveness. We also evaluated freedom from local regional recurrence and pharyngeal cancer-specific survival and performed supplementary analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>The study population included 960 patients equally divided into two groups. OS did not differ significantly between the T-IMRT and L-IMRT groups (hazard ratio for death: 0.82, p = 0.15, 5-year OS rate: 79 and 74% for T-IMRT and L-IMRT, respectively), and there were no significant differences in the other endpoints or supplementary analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>For LPC patients treated with definitive CCRT, we found no significant difference in disease control or survival between the T-IMRT and L-IMRT groups. However, further studies, especially randomized trials or studies focusing on other dimensions, such as quality of life, are needed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>We provide the first population-based study, as well as the largest study, on the clinical effectiveness of T-IMRT compared with L-IMRT in conjunction with CCRT in LPC patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20170947","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T16:39:01Z","timestamp":1521736741000},"source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of tomotherapy <i>v<\/i>\n\u00a0<i>s<\/i> linear accelerator image-guided intensity-modulated radiotherapy for localized pharyngeal cancer treated with definitive concurrent chemoradiotherapy: a Taiwanese population-based propensity score-matched analysis"],"prefix":"10.1093","volume":"91","author":[{"given":"Yao-Ching","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, China Medical University Hospital , Taichung , Taiwan"},{"name":"Department of Biomedical Imaging and Radiological Science, College of Health Care, China Medical University , Taichung , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2011Chin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, China Medical University Hospital , Taichung , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Ru","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, China Medical University Hospital , Taichung , Taiwan"},{"name":"School of Medicine, College of Medicine, China Medical University , Taichung , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"key":"2024050214225177500_b1","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1200\/JCO.2015.61.2994","article-title":"Advances in radiotherapy for head and neck cancer","volume":"33","author":"Gr\u00e9goire","year":"2015","journal-title":"J Clin Oncol"},{"key":"2024050214225177500_b2","unstructured":"National Comprehensive Cancer Network\n.\nNational comprehensive cancer network guideline for head and neck cancers, version 2\n.\n2017\n. 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