{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:40:33Z","timestamp":1782794433988,"version":"3.54.5"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1085","license":[{"start":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T00:00:00Z","timestamp":1518480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>This work proposes the use of mammographic breast density (MBD) to estimate actual glandular dose (AGD), and assesses how AGD compares to mean glandular dose (MGD) estimated using Dance et al method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>A retrospective sample of anonymised mammograms (52,405) was retrieved from a central database. Technical parameters and patient characteristics were exported from the Digital Imaging and Communication in Medicine (DICOM) header using third party software. LIBRA (Laboratory for Individualized Breast Radiodensity Assessment) software package (University of Pennsylvania, Philadelphia, USA) was used to estimate MBDs for each mammogram included in the data set. MGD was estimated using Dance et al method, while AGD was calculated by replacing Dance et al standard glandularities with LIBRA estimated MBDs. A linear regression analysis was used to assess the association between MGD and AGD, and a Bland-Altman analysis was performed to assess their mean difference.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>The final data set included 31,097 mammograms from 7728 females. MGD, AGD, and MBD medians were 1.53 , 1.62 mGy and 8% respectively. When stratified per breast thickness ranges, median MBDs were lower than Dance\u2019s standard glandularities. There was a strong positive correlation (R \u00a02 = 0.987, p &amp;lt; 0.0001) between MGD and AGD although the Bland-Altman analysis revealed a small statistically significant bias of 0.087 mGy between MGD and AGD (p &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>AGD estimated from MBD is highly correlated to MGD from Dance method, albeit the Dance method underestimates dose at smaller CBTs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>Our work should provide a stepping-stone towards an individualised dose estimation using automated clinical measures of MBD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20180032","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T15:08:55Z","timestamp":1517843335000},"source":"Crossref","is-referenced-by-count":12,"title":["Integrating mammographic breast density in glandular dose calculation"],"prefix":"10.1093","volume":"91","author":[{"given":"Moayyad E","family":"Suleiman","sequence":"first","affiliation":[{"name":"Medical Radiation Sciences, The University of Sydney, Faculty of Health Sciences. Cumberland Campus , Lidcombe, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C","family":"Brennan","sequence":"additional","affiliation":[{"name":"Medical Radiation Sciences, The University of Sydney, Faculty of Health Sciences. Cumberland Campus , Lidcombe, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Ekpo","sequence":"additional","affiliation":[{"name":"Medical Radiation Sciences, The University of Sydney, Faculty of Health Sciences. Cumberland Campus , Lidcombe, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kench","sequence":"additional","affiliation":[{"name":"Medical Radiation Sciences, The University of Sydney, Faculty of Health Sciences. Cumberland Campus , Lidcombe, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark F","family":"McEntee","sequence":"additional","affiliation":[{"name":"Medical Radiation Sciences, The University of Sydney, Faculty of Health Sciences. Cumberland Campus , Lidcombe, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,13]]},"reference":[{"key":"2024050214270252300_b1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ypmed.2011.05.011","article-title":"The evidence base for breast cancer screening","volume":"53","author":"Glasziou","year":"2011","journal-title":"Prev Med"},{"key":"2024050214270252300_b2","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1056\/NEJMsr1504363","article-title":"Breast-cancer screening--viewpoint of the IARC Working Group","volume":"372","author":"Lauby-Secretan","year":"2015","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"2024050214270252300_b3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1258\/jms.2012.012080","article-title":"Breast cancer mortality in mammographic screening in Europe: a review of incidence-based mortality studies","volume":"19","author":"Njor","year":"2012","journal-title":"J Med Screen"},{"key":"2024050214270252300_b4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1259\/bjr\/64009424","article-title":"Analysis of benefit:risk ratio and mortality reduction for the UK breast screening programme","volume":"76","author":"Beckett","year":"2003","journal-title":"Br J Radiol"},{"key":"2024050214270252300_b5","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1001\/jama.2014.13195","article-title":"JAMA patient page. 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