{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:17:02Z","timestamp":1793067422196,"version":"4.5.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"1093","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p>To evaluate CT texture analysis (CTTA) for non-invasively staging of hepatic fibrosis (stages F0-F4) in a cohort of patients with hepatitis C virus (HCV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Quantitative texture analysis of the liver was performed on abdominal multidimensional CT scans. Single slice region of interest measurements of the total liver, Couinaud segments IV\u2013VIII and segments I\u2013III were made. CT texture parameters were tested against stage of hepatic fibrosis in segments IV\u2013VIII on the portal venous phase. Texture parameters were correlated with biopsy performed within 1 year for all cases with intermediate fibrosis (F0\u2013F3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>CT scans of 556 adults (360 males, 196 females; mean age, 49.8 years), including a healthy control group (F0, n = 77) and patients with hepatitis C virus and Stage 0 disease (n = 49), and patients with increasing stages of fibrosis (F1, n = 80; F2 n = 99; F3 n = 87; F4 n = 164) were evaluated. Mean gray level intensity increased with increasing fibrosis. For significant fibrosis (\u2265F2), mean showed receiver operatingcharacteristic area under the curve (AUC) of 0.80 with sensitivity and specificity of 74 and 75% using a threshold of 0.44, with similar receiver operatingcharacteristic AUC and sensitivity\/specificity for advanced fibrosis (\u2265F3). Skewness and kurtosis were inversely associated with hepatic fibrosis, most prominently in cirrhotic patients. A multivariate model combining these four texture features (mean, mpp, skewness and kurtosis) showed slightly improved performance with AUC of 0.82, 0.82 and 0.86 for any fibrosis (F0 vs F1\u2013F4), significant fibrosis (F0\u20131 vs F2\u20134) and advanced fibrosis (F0\u20132 vs F3\u20134) respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>CT texture features may be associated with hepatic fibrosis and have utility in staging fibrosis, particularly at advanced levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Advances in knowledge:<\/jats:title><jats:p>CTTA may be helpful in detecting and staging hepatic fibrosis, particularly at advanced levels. CT measures like CTTA can be retrospectively evaluated without special equipment.<\/jats:p><\/jats:sec>","DOI":"10.1259\/bjr.20180153","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T09:22:09Z","timestamp":1536139329000},"source":"Crossref","is-referenced-by-count":40,"title":["CT texture analysis of the liver for assessing hepatic fibrosis in patients with hepatitis C virus"],"prefix":"10.1093","volume":"92","author":[{"given":"Meghan G","family":"Lubner","sequence":"first","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health , Madison, WI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Jones","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health , Madison, WI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kloke","sequence":"additional","affiliation":[{"name":"University of 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