{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:41:45Z","timestamp":1783384905358,"version":"3.54.6"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1097","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To clarify the cause of higher water fluctuation of the brain in idiopathic normal pressure hydrocephalus (iNPH), we assessed change in hemodynamic-independent apparent diffusion coefficient during the cardiac cycle (\u0394ADC) in iNPH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Electrocardiographically synchronized single-shot diffusion echo-planer imaging (b = 0, 500, and 1000\u2009s\/mm2) was performed in healthy volunteers, atrophic ventricular dilation group, and iNPH group, respectively. The \u0394ADC (b = 0\u2009and 1000\u2009s\/mm2) and maximum ADC (b = 0\u2009and 500\u2009s\/mm2) in the cardiac cycles were measured at the frontal white matter in the brain. Then, self-corrected \u0394ADC was obtained from the \u0394ADC divided by the maximum ADC (ADCpeak: perfusion-related diffusion) to correct the blood flow effect.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>The \u0394ADC after correction was significantly higher in the iNPH group than in the other two groups. However, there was no significant difference in ADCpeak values among the groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Self-corrected \u0394ADC in iNPH increased because of changes in the biomechanical properties of the brain. Self-corrected \u0394ADC analysis makes it possible to obtain information on hemodynamically independent water fluctuation as well as perfusion in iNPH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>Analysis self-corrected \u0394ADC provides simultaneously information on biomechanical properties, perfusion, and water fluctuation in iNPH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20180553","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T04:02:14Z","timestamp":1550116934000},"source":"Crossref","is-referenced-by-count":8,"title":["Hemodynamically self-corrected \u0394ADC analysis in idiopathic normal pressure hydrocephalus"],"prefix":"10.1093","volume":"92","author":[{"given":"Marina","family":"Takatsuji-Nagaso","sequence":"first","affiliation":[{"name":"Department of Radiology, Kouseiren Takaoka Hospital , Takaoka, Toyama , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tosiaki","family":"Miyati","sequence":"additional","affiliation":[{"name":"Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University , Kanazawa, Ishikawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Ohno","sequence":"additional","affiliation":[{"name":"Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University , Kanazawa, Ishikawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhito","family":"Mase","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Restorative Neuroscience, Graduate School of Medical Sciences, Nagoya City University , Nagoya, Aich , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harumasa","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Restorative Neuroscience, 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