{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:33:25Z","timestamp":1790814805360,"version":"4.1.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1100","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>The objectives of the study were to analyze the apparent diffusion coefficient (ADC), ktrans, kep metrics in dynamic contrast-enhanced multiparametric MRI (DCE-mpMRI) in biopsy proven cases of prostate cancer (PCa) and prostatitis and to establish \u201ccut-off\u201d values for various pharmacokinetic parameters that may distinguish PCa from chronic prostatitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>A retrospective review of all cases of PCa and chronic prostatitis patients, who underwent DCE-mpMRI in our institute was done from July 2017 to January 2019. Mean ADC, ktrans , kep for lesion \u201cL\u201d (ADCL, ktrans \u00a0L , kepL) and normal prostate tissue \u201cN\u201d (ADCN, ktrans \u00a0N , kepN ,) were calculated for each region of interest. Different ratios ADC ratio (defined as ADCL\/ ADCN), ktrans ratio (ktrans \u00a0L\/ ktrans \u00a0N), kepratio (kepL\/kepN) were calculated to differentiate PCa from chronic prostatitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Total of biopsy proven 14 cases of PCa and 18 cases of chronic prostatitis were included in the study. For ktrans ratio, the optimal cut-off was at 1.49 units where sensitivity was 85.7%, specificity was 61.1 % and Youden\u2019s index was 0.468 %. Similarly, optimal cut-offs determined for kep lesion was 0.86 (sensitivity 85.7%, specificity 66.7%, J = 0.524) and for kep ratio was 1.34 units (sensitivity 78.6%, specificity 66.7%, J = 0.543).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>DCE-mpMRI metrics could differentiate between PCa and chronic prostatitis with good specificity and sensitivity, while ProstateImaging Reporting and Data System v. 2 alone, did not differentiate between these patterns.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>ktrans ratio, kep lesion and kep ratio can differentiate PCa from chronic prostatitis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20190181","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T17:19:45Z","timestamp":1560273585000},"source":"Crossref","is-referenced-by-count":14,"title":["Quantitative contrast-enhanced perfusion kinetics in multiparametric MRI in differentiating prostate cancer from chronic prostatitis: results from a pilot study"],"prefix":"10.1093","volume":"92","author":[{"given":"Binit","family":"Sureka","sequence":"first","affiliation":[{"name":"Departments of Diagnostic & Interventional Radiology, All India Institute of Medical Sciences (AIIMS), Basni , Jodhpur, Rajasthan 342005 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Elhence","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Basni , Jodhpur, Rajasthan 342005 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpinder Singh","family":"Khera","sequence":"additional","affiliation":[{"name":"Departments of Diagnostic & Interventional Radiology, All India Institute of Medical Sciences (AIIMS), Basni , Jodhpur, Rajasthan 342005 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam Ram","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Departments of Urology, All India Institute of Medical Sciences (AIIMS), Basni , Jodhpur, Rajasthan 342005 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanshu","family":"Pandey","sequence":"additional","affiliation":[{"name":"Departments of Urology, All India Institute of Medical Sciences (AIIMS), Basni , Jodhpur, Rajasthan 342005 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan Kumar","family":"Garg","sequence":"additional","affiliation":[{"name":"Departments of Diagnostic & Interventional Radiology, All India Institute of Medical Sciences (AIIMS), Basni , Jodhpur, Rajasthan 342005 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuldeep","family":"Yadav","sequence":"additional","affiliation":[{"name":"Departments of Diagnostic & Interventional Radiology, All India Institute of Medical Sciences (AIIMS), Basni , Jodhpur, Rajasthan 342005 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil","family":"Goel","sequence":"additional","affiliation":[{"name":"Departments of Community Medicine and Family Medicine, All India Institute of Medical Sciences (AIIMS), Basni , Jodhpur, Rajasthan 342005 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"key":"2024050214461528700_b1","unstructured":"Globocan.iarc.fr\n          \n.\nGLOBOCAN Cancer Fact Sheets: prostate cancer\n.\n2012\n. Available from:\nhttp:\/\/globocan.iarc.fr\/ old\/FactSheets\/cancers\/prostate-new.asp.\n."},{"key":"2024050214461528700_b2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1148\/rg.313105139","article-title":"Advancements in MR imaging of the prostate: from diagnosis to interventions","volume":"31","author":"Bonekamp","year":"2011","journal-title":"Radiographics"},{"key":"2024050214461528700_b3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.eururo.2015.08.052","article-title":"PI-RADS Prostate Imaging - Reporting and Data System: 2015, Version 2","volume":"69","author":"Weinreb","year":"2016","journal-title":"Eur Urol"},{"key":"2024050214461528700_b4","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1007\/s00330-011-2377-y","article-title":"European Society of urogenital radiology. 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