{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:58:20Z","timestamp":1760014700505,"version":"3.41.2"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1105","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>This study investigated the occurrence of cardiotoxicity-related left-ventricular (LV) contractile dysfunction in breast cancer patients following treatment with antineoplastic chemotherapy agents.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>A validated and automated MRI-based LV contractility analysis tool consisting of quantization-based boundary detection, unwrapping of image phases and the meshfree Radial Point Interpolation Method was used toward measuring LV chamber quantifications (LVCQ), three-dimensional strains and torsions in patients and healthy subjects. Data were acquired with the Displacement Encoding with Stimulated Echoes (DENSE) sequence on 21 female patients and 21 age-matched healthy females. Estimates of patient LVCQs from DENSE acquisitions were validated in comparison to similar steady-state free precession measurements and their strain results validated via Bland\u2013Altman interobserver agreements. The occurrence of LV abnormalities was investigated via significant differences in contractility measurements (LVCQs, strains and torsions) between patients and healthy subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Repeated measures analysis showed similarities between LVCQ measurements from DENSE and steady-state free precession, including cardiac output (4.7 \u00b1 0.4 L, 4.6 \u00b1 0.4 L, p = 0.8), and LV ejection fractions (59\u00b16%, 58\u00b15%, p = 0.2). Differences found between patients and healthy subjects included enlarged basal diameter (5.0 \u00b1 0.5\u2009cm vs 4.4 \u00b1 0.5\u2009cm, p &amp;lt; 0.01), apical torsion (6.0 \u00b1 1.1\u00b0 vs 9.7 \u00b1 1.4\u00b0, p &amp;lt; 0.001) and global longitudinal strain (\u22120.15 \u00b1 0.02 vs. -0.21 \u00b1 0.04, p &amp;lt; 0.001), but not LV ejection fraction (59\u00b16% vs. 63\u00b16%, p = 0.1).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>The results from the statistical analysis reveal the possibility of LV abnormalities in the post-chemotherapy patients via enlarged basal diameter and reduced longitudinal strain and torsion, in comparison to healthy subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>This study shows that subclinical LV abnormalities in post-chemotherapy breast cancer patients can be detected with an automated technique for the comprehensive analysis of contractile parameters.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20190289","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T16:36:50Z","timestamp":1571243810000},"source":"Crossref","is-referenced-by-count":6,"title":["Fully automated and comprehensive MRI-based left-ventricular contractility analysis in post-chemotherapy breast cancer patients"],"prefix":"10.1093","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1140-4310","authenticated-orcid":false,"given":"Julia","family":"Kar","sequence":"first","affiliation":[{"name":"Departments of Mechanical Engineering and Pharmacology, University of South Alabama , 150 Jaguar Drive, Mobile, AL 36688 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael V.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, College of Medicine University of South Alabama , 1700 Center Street, Mobile, AL 36604 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel A.","family":"McQuiston","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of South Alabama , 2451 USA Medical Center Drive, Mobile, AL 36617 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S.","family":"Figarola","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of South Alabama , 2451 USA Medical Center Drive, Mobile, AL 36617 , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Malozzi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, College of Medicine University of South Alabama , 1700 Center Street, Mobile, AL 36604 , United 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