{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:20:07Z","timestamp":1762543207127,"version":"3.41.2"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1110","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>Our study aimed to compare regional node coverage and doses to the organ at risk (OAR) using conventional technique (CT) vs \u201cAMAROS\u201d (AT) vs intensity-modulated radiation therapy (IMRT) techniques in patients receiving regional nodal irradiation (RNI) for breast cancer (BC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>We included 30 consecutive patients with BC who received RNI including axillary nodes. Two independent and blinded dosimetric RNI plans were generated for all patients. For target volume coverage, we analyzed the V95%, the D95%, the mean and the minimal dose within the nodal station. For hotspots within nodal target volume, we used the V105%, the V108% and the maximal doses. For OAR, lung V20, mean lung and heart doses, the maximal dose to the brachial plexus and the axillary-lateral thoracic vessel junction region were compared between the three techniques.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Target volume coverage and hotspots: Mean V95% in stations I, II, III and IV were 35.8% and 75% respectively with CV, 22.59 and 59.9% respectively with AT technique and 45.58 and 99.6% respectively with IMRT with statistically significant differences (p &amp;lt; 0.001). Mean V105% (cc) in axillary and supraclavicular stations were 21.3 and 6.4 respectively with CV, 1.2 and 0.02 respectively with AT technique and 0.5 and 0.4 respectively with IMRT with statistically significant differences (p &amp;lt; 0.001)..<\/jats:p>\n                  <jats:p>OARs: The mean ipsilateral lung V20 was 16.9%, 16.4 and 13.3% with CT, AT and IMRT respectively. The mean heart dose (Gy) was 0.3, 0.2 and 0.2 with CT, AT and IMRT respectively. The maximal dose to the plexus brachial (Gy) was 50.3, 46.3 and 47.3 with CT, AT and IMRT respectively. The maximal dose to the axillary-lateral thoracic vessel junction (Gy) was 52.3, 47.3 and 47.6 with CT, AT and IMRT respectively. The differences were statistically significant for all OAR (p &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>AT is a valuable technique for RNI including axilla in patients with limited sentinel lymph node biopsy involvement without additional axillary lymph node dissection since it decreases hotspots in the target volume and lowers the radiation exposure of the OAR. For more advanced tumors or patients who did not respond to primary systemic therapy, CT or IMRT should be considered because of their better coverage of the potentially residual nodal disease. IMRT combines several advantages of offering high conformal plans, limited hotspots and protection of main OAR. The clinical impact of these dosimetric differences need to be addressed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>This study is to our knowledge the first to compare conventional three-dimensional and IMRT techniques for regional nodal irradiation for each nodal station in breast cancer in a context of increasing utilization of axillary irradiation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20190351","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T17:36:51Z","timestamp":1585762611000},"source":"Crossref","is-referenced-by-count":5,"title":["Axillary nodal irradiation practice in the sentinel lymph node biopsy era: Comparison of the contemporary available 3D and IMRT techniques"],"prefix":"10.1093","volume":"93","author":[{"given":"Yazid","family":"Belkacemi","sequence":"first","affiliation":[{"name":"AP-HP. Department of Radiation Oncology and Henri Mondor Breast Center , Cr\u00e9teil , France"},{"name":"University of Paris-Est (UPEC) , Cr\u00e9teil , France"},{"name":"INSERM Unit 955 team 21, Institut Mondor de Recherche Biom\u00e9dicale , Cr\u00e9teil , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokoulakrichenane","family":"Loganadane","sequence":"additional","affiliation":[{"name":"AP-HP. Department of Radiation Oncology and Henri Mondor Breast Center , Cr\u00e9teil , France"},{"name":"University of Paris-Est (UPEC) , Cr\u00e9teil , France"},{"name":"INSERM Unit 955 team 21, Institut Mondor de Recherche Biom\u00e9dicale , Cr\u00e9teil , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Ghith","sequence":"additional","affiliation":[{"name":"AP-HP. Department of Radiation Oncology and Henri Mondor Breast Center , Cr\u00e9teil , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xie","family":"Li","sequence":"additional","affiliation":[{"name":"AP-HP. Department of Radiation Oncology and Henri Mondor Breast Center , Cr\u00e9teil , France"},{"name":"Department of Radiation Oncology for Gynecologic Tumors, Anti-Cancer Center and Tumor Hospital of the Xinjiang Medical University , Urumqi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soufya","family":"Majdoul","sequence":"additional","affiliation":[{"name":"AP-HP. Department of Radiation Oncology and Henri Mondor Breast Center , Cr\u00e9teil , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9mie","family":"Grellier","sequence":"additional","affiliation":[{"name":"AP-HP. Department of Radiation Oncology and Henri Mondor Breast Center , Cr\u00e9teil , France"},{"name":"University of Paris-Est (UPEC) , Cr\u00e9teil , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Jmour","sequence":"additional","affiliation":[{"name":"AP-HP. Department of Radiation Oncology and Henri Mondor Breast Center , Cr\u00e9teil , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy Le","family":"Bret","sequence":"additional","affiliation":[{"name":"AP-HP. Department of Radiation Oncology and Henri Mondor Breast Center , Cr\u00e9teil , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Laure","family":"Herv\u00e9","sequence":"additional","affiliation":[{"name":"AP-HP. Department of Radiation Oncology and Henri Mondor Breast Center , Cr\u00e9teil , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Hadhri","sequence":"additional","affiliation":[{"name":"AP-HP. Department of Radiation Oncology and Henri Mondor Breast Center , Cr\u00e9teil , France"},{"name":"University of Medicine of Tunis-El Manar , Tunis , Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nhu Hanh","family":"To","sequence":"additional","affiliation":[{"name":"AP-HP. Department of Radiation Oncology and Henri Mondor Breast Center , Cr\u00e9teil , France"},{"name":"University of Paris-Est (UPEC) , Cr\u00e9teil , France"},{"name":"INSERM Unit 955 team 21, Institut Mondor de Recherche Biom\u00e9dicale , Cr\u00e9teil , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryse","family":"Fayolle-Campana","sequence":"additional","affiliation":[{"name":"AP-HP. Department of Radiation Oncology and Henri Mondor Breast Center , Cr\u00e9teil , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurianne","family":"Colson-Durand","sequence":"additional","affiliation":[{"name":"AP-HP. 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