{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:27:41Z","timestamp":1775575661344,"version":"3.50.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1108","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>In spite of the well-known importance of thalamus in hemifacial spasm (HFS), the thalamic resting-state networks in HFS is still rarely mentioned. This study aimed to investigate resting-state functional connectivity (FC) of the thalamus in HFS patients and examine its association with clinical measures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>25 HFS patients and 28 matched healthy controls underwent functional MRI at rest. Using the left and right thalamus as seed regions respectively, we compared the thalamic resting-state networks between patient and control groups using two independent sample t-test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Compared with controls, HFS patients exhibited strengthened bilateral thalamus-seeded FC with the parietal cortex. Enhanced FC between right thalamus and left somatosensory association cortex was linked to worse motor disturbance, and the increased right thalamus-right supramarginal gyrus connection were correlated with improvement of affective symptoms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Our findings indicate that the right thalamus\u2013left somatosensory association cortex hyperconnectivity may represent the underlying neuroplasticity related to sensorimotor dysfunction. In addition, the upregulated FC between the right thalamus and right supramarginal gyrus in HFS, is part of the thalamo-default mode network pathway involved in emotional adaptation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>This study provides new insights on the integrative role of thalamo-parietal connectivity, which participates in differential neural circuitry as a mechanism underlying motor and emotional functions in HFS patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20190887","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T16:56:11Z","timestamp":1578329771000},"source":"Crossref","is-referenced-by-count":11,"title":["Strengthened thalamoparietal functional connectivity in patients with hemifacial spasm: a cross-sectional resting-state fMRI study"],"prefix":"10.1093","volume":"93","author":[{"given":"Xuan","family":"Niu","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an 710061 , PR China"},{"name":"Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi\u2019an Jiaotong University , Xi'an 710049 , PR China"},{"name":"Washington University School of Medicine , St. Louis, MO 63110 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an 710061 , PR China"},{"name":"Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi\u2019an Jiaotong University , Xi'an 710049 , PR 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