{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:16:53Z","timestamp":1781180213114,"version":"3.54.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1118","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>To compare CT-guided transthoracic cutting needle biopsy (TCNB) with transthoracic aspiration needle biopsy (TANB) for pulmonary lesions with respect to the diagnostic accuracy and complication rate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Of the 859 cases that underwent consecutive CT-guided biopsy of pulmonary lesions, 713 cases confirmed by surgical pathology or clinical follow-up were enrolled. Of these, the first consecutive 275 cases underwent TANB, and the remaining 438 received TCNB. The final diagnosis determined the accuracy of biopsy. Based on the post-biopsy CT and clinical medical records, the presence or absence of biopsy-related complications was determined. The \u03c72 test was used to compare the differences between TCNB and TANB in terms of diagnostic accuracy and complication rate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Among the 713 biopsy lesions, the final diagnosis was malignant in 411 cases and benign in 302 cases. As compared to TANB, the diagnostic accuracy of TCNB (98.9% vs 93.8%, \u03c72 = 14.35, p &amp;lt; 0.01), sensitivity to malignant lesions (97.8% vs 90.6%, \u03c72 = 10.58, p &amp;lt; 0.01), negative predictive value (97.6% vs 84.8%, \u03c72 = 19.03, p &amp;lt; 0.01), and specific diagnostic rate for benign lesions (73.4% vs 57.9%, \u03c72 = 7.29, p &amp;lt; 0.01) were improved. On the other hand, a statistical difference was detected between TCNB and TANB with respect to the incidence of pneumothorax (20.6% vs 13.1%, \u03c72 = 6.46, p = 0.01), hemorrhage (32.2% vs 13.1%, \u03c72 = 33.03, p &amp;lt; 0.01), and hemoptysis (8.2% vs 3.3%, \u03c72 = 6.87, p &amp;lt; 0.01). One patient died just several minutes after TCNB due to severe hemorrhage with hemoptysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Compared to TANB, CT-guided TCNB improves the diagnostic accuracy of pulmonary lesions, but complication rate increases significantly.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>In general, TCNB should be recommended, especially for highly suspicious benign lesions. For patients with small lesions adjacent to vessels or vessels within the lesion, TANB should be considered.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20190930","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T19:30:32Z","timestamp":1606505432000},"source":"Crossref","is-referenced-by-count":15,"title":["CT-guided transthoracic needle biopsy of pulmonary lesions: comparison between the cutting needle and aspiration needle"],"prefix":"10.1093","volume":"94","author":[{"given":"Zhen-guo","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiology, China-Japan Friendship Hospital , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-liang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology, China-Japan Friendship Hospital , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cun-li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, No.3 Hospital of Bao Tou City , Baotou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiology, China-Japan Friendship Hospital , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, China-Japan Friendship Hospital , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-xing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, China-Japan Friendship Hospital , Beijing , 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