{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T14:16:18Z","timestamp":1768140978894,"version":"3.49.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1110","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>Ultrasound elastography is increasingly used in the diagnosis of prostate cancer, however results are heterogeneous. We correlate in a large sample-size prospective study the accuracy of elastography, aiming to settle an accurate cut-off point for diagnosis and possibility of use as a screening tool.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Prospective study that included 120 patients with mean age 59.5\u2009\u00b1\u20099.8 years, showing enlarged prostate by clinical examination with prostate-specific antigen &amp;gt;4\u2009ng\u2009ml\u22121.<\/jats:p>\n                  <jats:p>The study was done using high frequency high resolution endorectal probe with real time tissue elastography.<\/jats:p>\n                  <jats:p>Grayscale ultrasound examination was done first with Doppler followed by elastography color-coded map and strain ratio measurement. Then, transrectal ultrasound-guided core biopsy was done from suspicious areas detected by elastography (totally or partly stiff by color-coded map or with relative increased strain ratio), besides standard six-quadrant core biopsy samples.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>There was statistically significant difference (p &amp;lt; 0.001) regarding strain ratio in benign and malignant lesions. Strain ratio showed significant proportionate correlation with prostate-specific antigen level and Gleason pathological score, while no significant correlation noted with the age or the prostatic volume. A strain ratio with a cut-off value of 1.9 showed a sensitivity of 100%, specificity 93.8%, positive predictive value of 79.3%, negative predictive value 100 and 95% accuracy in differentiating between malignant and benign lesions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Strain ratio improves the detection of prostatic cancer with high sensitivity (100%) and high negative predictive value (100%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>Different prostatic lesions are mostly similar in grayscale ultrasound.<\/jats:p>\n                  <jats:p>Imaging plays an important role in differentiation of prostatic nodules.<\/jats:p>\n                  <jats:p>Ultrasound elastography may play an important role in distinguishing benign from malignant nodules.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20200035","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T18:11:32Z","timestamp":1583518292000},"source":"Crossref","is-referenced-by-count":12,"title":["Ultrasound elastography in characterization of prostatic lesions: correlation with histopathological findings"],"prefix":"10.1093","volume":"93","author":[{"given":"Doaa M","family":"Emara","sequence":"first","affiliation":[{"name":"Department of radiodiagnosis and intervention, faculty of medicine, Alexandria university , Alexandria , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagy N.","family":"Naguib","sequence":"additional","affiliation":[{"name":"AMEOS Hospital Halberstadt , Halberstadt , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Yehia","sequence":"additional","affiliation":[{"name":"Department of Urology, faculty of medicine, Alexandria university , Alexandria , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed M.","family":"El Shafei","sequence":"additional","affiliation":[{"name":"Department of radiodiagnosis and intervention, faculty of medicine, Alexandria university , Alexandria , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"key":"2024050215285584600_b1","doi-asserted-by":"crossref","first-page":"e509","DOI":"10.1016\/S1470-2045(12)70388-1","article-title":"Do low-grade and low-volume prostate cancers bear the hallmarks of malignancy?","volume":"13","author":"Ahmed","year":"2012","journal-title":"Lancet Oncol"},{"key":"2024050215285584600_b2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.diii.2013.01.017","article-title":"Ultrasound elastography of the prostate: state of the art","volume":"94","author":"Correas","year":"2013","journal-title":"Diagn Interv 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