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Screening for malignancy is based on the assumption that cancer has a gradual, orderly progression and that detecting lesions earlier in their natural history, and intervening, will reduce mortality. The natural history of epithelial atypia, ductal carcinoma in situ and even invasive breast cancer is poorly understood, but widely variable. We believe that population breast screening methodology needs to change to focus on diagnosis of lesions of greatest clinical relevance. <\/jats:p>","DOI":"10.1259\/bjr.20200135","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T19:31:15Z","timestamp":1597951875000},"page":"20200135","source":"Crossref","is-referenced-by-count":0,"title":["Screening detects a myriad of breast disease \u2013 refining practice will increase effectiveness and reduce harm"],"prefix":"10.1093","volume":"93","author":[{"given":"Iain D","family":"Lyburn","sequence":"first","affiliation":[{"name":"Cheltenham Imaging Centre, Cobalt Medical Charity, Cheltenham, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E","family":"Pinder","sequence":"additional","affiliation":[{"name":"School of Cancer & Pharmaceutical Sciences, King's College, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.TPS603"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_159060"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019180760"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7464.477"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.177"},{"key":"b7","first-page":"3812","volume":"29","author":"Blanks RG","year":"2019","journal-title":"Eur"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25801"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2011.01.009"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6059-0"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-3254-6"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2018.04.004"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2017.12.007"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-005-9101-z"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00446-5"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb00213.x"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1136\/jms.8.2.86"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2013.06.006"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5644"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds586"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1111\/his.13642"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3886"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1799-6"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1206809"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2019.11.005"},{"key":"b27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903986"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.0572"}],"container-title":["The British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.birpublications.org\/doi\/pdf\/10.1259\/bjr.20200135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T16:37:52Z","timestamp":1705077472000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/7240248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,1]]},"references-count":26,"journal-issue":{"issue":"1115","published-print":{"date-parts":[[2020,11,1]]}},"alternative-id":["10.1259\/bjr.20200135"],"URL":"https:\/\/doi.org\/10.1259\/bjr.20200135","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,1]]}}}