{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:05:51Z","timestamp":1753884351232,"version":"3.41.2"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1112","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>To assess the associations between automated volumetric estimates of mammographic asymmetry and breast cancers detected at the same (\u201ccontemporaneous\u201d) screen, at subsequent screens, or in between (interval cancers).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Automated measurements from mammographic images (N = 79,731) were used to estimate absolute asymmetry in breast volume (BV) and dense volume (DV) in a large ethnically diverse population of attendees of a UK breast screening programme. Logistic regression models were fitted to assess asymmetry associations with the odds of a breast cancer detected at contemporaneous screen (767 cases), adjusted for relevant confounders.<\/jats:p>\n                  <jats:p>Nested case\u2013control investigations were designed to examine associations between asymmetry and the odds of: (a) interval cancer (numbers of cases\/age-matched controls: 153\/646) and (b) subsequent screen-detected cancer (345\/1438), via conditional logistic regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>DV, but not BV, asymmetry was positively associated with the odds of contemporaneous breast cancer (P-for-linear-trend (Pt) = 0.018). This association was stronger for first (prevalent) screens (Pt = 0.012). Both DV and BV asymmetry were positively associated with the odds of an interval cancer diagnosis (Pt = 0.060\u2009and 0.030, respectively). Neither BV nor DV asymmetry were associated with the odds of having a subsequent screen-detected cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Increased DV asymmetry was associated with the risk of a breast cancer diagnosis at a contemporaneous screen or as an interval cancer. BV asymmetry was positively associated with the risk of an interval cancer diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>The findings suggest that DV and BV asymmetry may provide additional signals for detecting contemporaneous cancers and assessing the likelihood of interval cancers in population-based screening programmes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20200154","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T20:40:33Z","timestamp":1591908033000},"source":"Crossref","is-referenced-by-count":5,"title":["Left\u2013right breast asymmetry and risk of screen-detected and interval cancers in a large population-based screening population"],"prefix":"10.1093","volume":"93","author":[{"given":"Sue M","family":"Hudson","sequence":"first","affiliation":[{"name":"Department of Non-Communicable Disease 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