{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:30:32Z","timestamp":1783549832091,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1114","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To evaluate the efficiency of high-energy photons for mitigating alopecia due to whole-brain irradiation (WBRT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Planning CT data from 10 patients who received WBRT were collected. We prepared 4 WBRT plans that used 6 or 15\u2009MV photon beams, with or without use of a field-in-field (FiF) technique, and compared outcomes using a treatment planning system. The primary outcome was dose parameters to the scalp, including the mean dose, maximum dose, and dose received to 50% scalp<\/jats:p>\n                  <jats:p>(D50%). Secondary outcomes were minimum dose to the brain surface.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Using FiF, the mean doses were 24.4\u201326.0 and 22.4\u201324.1\u2009Gy, and the maximum doses were 30.5\u201332.1 and 28.5\u201330.8\u2009Gy for 6 and 15\u2009MV photon beams, respectively. Without FiF, the mean doses were 24.6\u201326.9 and 22.6\u201324.5\u2009Gy, and the maximum doses were 30.8\u201334.6 and 28.6\u201332.4\u2009Gy for 6 and 15\u2009MV photon beams. The 15\u2009MV plan resulted in a lower scalp dose for each dose parameter (p &amp;lt; 0.001). Using FiF, the minimum doses to the brain surface for the 6 and 15\u2009MV plans were 28.9 \u00b1 0.440\u2009and 29.0 \u00b1 0.557\u2009Gy, respectively (p = 0.70). Without FiF, the minimum doses to the brain surface for the 6 and 15\u2009MV plans were 28.9 \u00b1 0.456\u2009and 29.0 \u00b1 0.529, respectively (p = 0.66).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Compared with the 6\u2009MV plan, the 15\u2009MV plan achieved a lower scalp dose without impairing the brain surface dose.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>High-energy photon WBRT may mitigate alopecia of patients who receiving WBRT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20200159","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T16:35:07Z","timestamp":1594398907000},"source":"Crossref","is-referenced-by-count":6,"title":["Dosimetric study of whole-brain irradiation with high-energy photon beams for dose reduction to the scalp"],"prefix":"10.1093","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2797-8469","authenticated-orcid":false,"given":"Masafumi","family":"Sawada","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Tokai University School of Medicine , Isehara, Kanagawa , Japan"},{"name":"Department of Radiation Oncology, Keio University School of Medicine, Shinjuku , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuo","family":"Kunieda","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tokai University School of Medicine , Isehara, Kanagawa , Japan"},{"name":"Department of Radiation Oncology, Keio University School of Medicine, Shinjuku , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Akiba","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tokai University School of Medicine , Isehara, Kanagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeto","family":"Kabuki","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tokai University School of Medicine , Isehara, Kanagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuta","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tokai University School of Medicine , Isehara, Kanagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Fukuzawa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tokai University School of Medicine , Isehara, Kanagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitsugu","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tokai University School of Medicine , Isehara, Kanagawa , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Shigematsu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Keio University School of Medicine, Shinjuku , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"2024050215303731800_b1","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1002\/cncr.10541","article-title":"Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma","volume":"94","author":"Schouten","year":"2002","journal-title":"Cancer"},{"key":"2024050215303731800_b2","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1200\/JCO.2004.12.149","article-title":"Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the metropolitan Detroit cancer surveillance 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