{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:30:35Z","timestamp":1772213435279,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1119","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>To analyze vertebral fractures risk in patients with chest scans by evaluating vertebral hydroxyapatite concentration measured on spectral CT compared to trabecular attenuation value measured on conventional CT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Our retrospective study reviewed CT of 216 patients. Analysis of vertebral (T11 \u2013 L1) hydroxyapatite concentration by spectral imaging and trabecular attenuation value by conventional CT imaging were performed in patients with chest CT examinations. Specificity, sensitivity, negative predictive value (NPV), and positive predictive value (PPV) were performed by using receiver operating characteristic (ROC) curves in patients with and without vertebral fractures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>In male patients, vertebral hydroxyapatite concentration had high area under the ROC curve (0.916), by using the optimal threshold of 72.27\u2009mg\/cm3, specificity, sensitivity, NPV, and PPV were 91.7, 80.2, 36.7, and 98.7%, respectively. In female patients, vertebral hydroxyapatite concentration also had high area under the ROC curve (0.870), by using the optimal threshold of 74.79\u2009mg\/cm3, specificity, sensitivity, NPV, and PPV were 100.0, 77.8, 47.4, and 100.0%, respectively. Area under the ROC curve was significantly different between spectral CT-measured bone hydroxyapatite concentration and conventional CT-measured attenuation value in distinguishing vertebral fractures (p = 0.007 for males; p = 0.005 for females).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Quantitative assessment with spectral CT may appear as higher accuracy than that of conventional CT imaging to analyze risk of vertebral fractures. Hydroxyapatite concentration measured with chest spectral CT may be used to evaluate risk of bone fractures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>Hydroxyapatite concentration measured with chest spectral CT may be used to evaluate risk of bone fractures.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20200234","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T18:48:43Z","timestamp":1610131723000},"source":"Crossref","is-referenced-by-count":5,"title":["Risk of vertebral fractures: evaluation on vertebral trabecular attenuation value and hydroxyapatite concentration in patients by chest spectral CT"],"prefix":"10.1093","volume":"94","author":[{"given":"Qiang","family":"Ma","sequence":"first","affiliation":[{"name":"Radiology Department, Capital Medical University Affiliated Beijing Friendship Hospital , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmeng","family":"Hou","sequence":"additional","affiliation":[{"name":"Radiology Department, Capital Medical University Affiliated Beijing Friendship Hospital , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyue","family":"Cheng","sequence":"additional","affiliation":[{"name":"Radiology Department, Capital Medical University Affiliated Beijing Friendship Hospital , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuangang","family":"You","sequence":"additional","affiliation":[{"name":"Beijing Tropical Medicine Research Institute, Capital Medical University Affiliated Beijing Friendship Hospital , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghan","family":"Yang","sequence":"additional","affiliation":[{"name":"Radiology Department, Capital Medical University Affiliated Beijing Friendship Hospital , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Radiology Department, Capital Medical University Affiliated Beijing Friendship Hospital , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenchang","family":"Wang","sequence":"additional","affiliation":[{"name":"Radiology Department, Capital Medical University Affiliated Beijing Friendship Hospital , Beijing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"2024050215221178000_b1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJMcp1513724","article-title":"Postmenopausal osteoporosis","volume":"374","author":"Black","year":"2016","journal-title":"N Engl J Med"},{"key":"2024050215221178000_b2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.7326\/0003-4819-158-8-201304160-00003","article-title":"Opportunistic screening for osteoporosis using abdominal computed tomography scans obtained for other indications","volume":"158","author":"Pickhardt","year":"2013","journal-title":"Ann Intern Med"},{"key":"2024050215221178000_b3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2214\/AJR.17.17853","article-title":"Prevalence of vertebral compression fractures on routine CT scans according to L1 trabecular attenuation: determining relevant thresholds for opportunistic osteoporosis screening","volume":"209","author":"Graffy","year":"2017","journal-title":"AJR Am J Roentgenol"},{"key":"2024050215221178000_b4","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/s00198-019-04977-w","article-title":"Vertebral bone attenuation in Hounsfield units and prevalent vertebral fractures are associated with the short-term risk of vertebral fractures in current and ex-smokers with and without COPD: a 3-year chest CT follow-up study","volume":"30","author":"van Dort","year":"2019","journal-title":"Osteoporos Int"},{"key":"2024050215221178000_b5","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1148\/radiol.2019181648","article-title":"Opportunistic osteoporosis screening at routine abdominal and thoracic CT: normative L1 trabecular attenuation values in more than 20 000 adults","volume":"291","author":"Jang","year":"2019","journal-title":"Radiology"},{"key":"2024050215221178000_b6","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1007\/s00330-019-06263-z","article-title":"Bone mineral density measurements derived from dual-layer spectral CT enable opportunistic screening for osteoporosis","volume":"29","author":"Roski","year":"2019","journal-title":"Eur Radiol"},{"key":"2024050215221178000_b7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1148\/radiol.2016161797","article-title":"Influence of parathyroidectomy on bone calcium concentration: evaluation with spectral CT in patients with secondary hyperparathyroidism undergoing Hemodialysis-a prospective feasibility study","volume":"284","author":"Ma","year":"2017","journal-title":"Radiology"},{"key":"2024050215221178000_b8","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2214\/AJR.17.18394","article-title":"Discrimination between calcium hydroxyapatite and calcium oxalate using Multienergy spectral photon-counting CT","volume":"209","author":"Kirkbride","year":"2017","journal-title":"AJR Am J Roentgenol"},{"key":"2024050215221178000_b9","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s00330-012-2622-z","article-title":"Review of radiological scoring methods of osteoporotic vertebral fractures for clinical and research settings","volume":"23","author":"Oei","year":"2013","journal-title":"Eur Radiol"},{"key":"2024050215221178000_b10","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1148\/radiology.148.3.6878708","article-title":"A method of comparing the areas under receiver operating characteristic curves derived from the same cases","volume":"148","author":"Hanley","year":"1983","journal-title":"Radiology"},{"key":"2024050215221178000_b11","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1148\/radiol.2019190434","article-title":"Screening of bone density at CT: an overlooked opportunity","volume":"291","author":"Smith","year":"2019","journal-title":"Radiology"},{"key":"2024050215221178000_b12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00198-016-3724-2","article-title":"Vertebral bone attenuation on low-dose chest CT: quantitative volumetric analysis for bone fragility assessment","volume":"28","author":"Kim","year":"2017","journal-title":"Osteoporos Int"},{"key":"2024050215221178000_b13","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s00198-011-1693-z","article-title":"Lumbar spine bone mineral density in US adults: demographic patterns and relationship with femur neck skeletal status","volume":"23","author":"Looker","year":"2012","journal-title":"Osteoporos Int"},{"key":"2024050215221178000_b14","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/jbmr.3383","article-title":"Future osteoporotic fracture risk related to lumbar vertebral trabecular attenuation measured at routine body CT","volume":"33","author":"Lee","year":"2018","journal-title":"J Bone Miner Res"}],"container-title":["The British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/94\/1119\/20200234\/57375171\/bjr.20200234.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/94\/1119\/20200234\/57375171\/bjr.20200234.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T15:56:32Z","timestamp":1714665392000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/doi\/10.1259\/bjr.20200234\/7451681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,19]]},"references-count":14,"journal-issue":{"issue":"1119","published-online":{"date-parts":[[2021,1,19]]},"published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1259\/bjr.20200234","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3,1]]},"published":{"date-parts":[[2021,1,19]]},"article-number":"20200234"}}