{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:40:14Z","timestamp":1788957614590,"version":"build-2803163510"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1121","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>To assess if excess absolute risk (EAR) of radiation-induced solid cancer can be used to rank radiotherapy plans for treatment of Hodgkin lymphoma (HL) in a statistically significant way.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>EAR models, calibrated with data from the Life Span Study and HL survivors, have been incorporated into a voxelised risk-calculation software, which is used to compare four treatment modalities planned for five virtual HL patients. Organ-specific parameters are generated repeatedly in a Monte Carlo fashion to model their uncertainties. This in turn enables a quantitative estimation of the EAR uncertainties.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Parameter-driven uncertainties on total EAR are around 13%, decreasing to around 2\u20135% for relative EAR comparisons. Total EAR estimations indicate that intensity modulated proton therapy decreases the average risk by 40% compared to the intensity modulated radiation therapy plan, 28% compared to the volumetric modulated arc therapy plan whereas the three-dimensional conformal radiation therapy plan is equivalent within the uncertainty.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Relative EAR is a useful metric for distinguishing between radiotherapy plans in terms of second cancer risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>Relative EAR is not dominated by model or parameter uncertainties and can be used to guide the choice of radiotherapy for HL patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20200354","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T21:14:22Z","timestamp":1606338862000},"source":"Crossref","is-referenced-by-count":12,"title":["Comparing second cancer risk for multiple radiotherapy modalities in survivors of hodgkin lymphoma"],"prefix":"10.1093","volume":"94","author":[{"given":"Claire","family":"Timlin","sequence":"first","affiliation":[{"name":"Particle Therapy Cancer Research Institute, University of Oxford , Oxford , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Loken","sequence":"additional","affiliation":[{"name":"Particle Therapy Cancer Research Institute, University of Oxford , Oxford , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Kruse","sequence":"additional","affiliation":[{"name":"Mayo Clinic , Rochester, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Miller","sequence":"additional","affiliation":[{"name":"Mayo Clinic , Rochester, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Zurich and Radiotherapy Hirslanden , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"key":"2024050215492795400_b1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1667\/RR2629.1","article-title":"Studies of the mortality of atomic bomb survivors, report 14, 1950-2003: an overview of cancer and noncancer diseases","volume":"177","author":"Ozasa","year":"2012","journal-title":"Radiat Res"},{"key":"2024050215492795400_b2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/09553000410001695895","article-title":"The crooked shall be made straight doseresponse relationships for carcinogenesis","volume":"80","author":"Hall","year":"2004","journal-title":"Int J Radiat Biol"},{"key":"2024050215492795400_b3","first-page":"3484","article-title":"\u201cSecond malignant neoplasms among long-term survivors of Hodgkin\u2019s disease: a population-based evaluation over 25 years\u201d, J","volume":"20","author":"Dores","year":"2002","journal-title":"Clin. 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Available from:\nhttps:\/\/www.research-collection.ethz.ch\/handle\/20.500.11850\/443206\n."},{"key":"2024050215492795400_b14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1118\/1.4903272","article-title":"Assessment of uncertainties in radiation-induced cancer risk predictions at clinically relevant doses","volume":"42","author":"Nguyen","year":"2015","journal-title":"Med Phys"},{"key":"2024050215492795400_b15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1748-717X-8-22","article-title":"Hodgkin's lymphoma emerging radiation treatment techniques: trade-offs between late radio-induced toxicities and secondary malignant neoplasms","volume":"8","author":"Cella","year":"2013","journal-title":"Radiat Oncol"},{"key":"2024050215492795400_b16","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1748-717X-9-58","article-title":"Radiation-Induced second malignancies after involved-node radiotherapy with deep-inspiration breath-hold technique for early stage Hodgkin lymphoma: a dosimetric study","volume":"9","author":"Schneider","year":"2014","journal-title":"Radiat Oncol"},{"key":"2024050215492795400_b17","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0360-3016(01)02826-7","article-title":"Secondary neutron dose during proton therapy using spot scanning","volume":"53","author":"Schneider","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2024050215492795400_b18","first-page":"553","article-title":"Induction of chromosome aberrations by 4.9 MeV protons in human lymphocytes","volume":"44","author":"Takatsuji","year":"1983","journal-title":"Int J Radiat Biol"},{"key":"2024050215492795400_b19","first-page":"137","article-title":"Chromosome aberrations induced in human lymphocytes by 8.7 MeV protons and 23.5 MeV helium-3 ions","volume":"50","author":"Edwards","year":"1986","journal-title":"Int J Radiat Biol"}],"container-title":["The British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/94\/1121\/20200354\/57374719\/bjr.20200354.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/94\/1121\/20200354\/57374719\/bjr.20200354.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T16:47:03Z","timestamp":1714668423000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/doi\/10.1259\/bjr.20200354\/7476748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,9]]},"references-count":19,"journal-issue":{"issue":"1121","published-online":{"date-parts":[[2021,4,9]]},"published-print":{"date-parts":[[2021,5,1]]}},"URL":"https:\/\/doi.org\/10.1259\/bjr.20200354","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,5,1]]},"published":{"date-parts":[[2021,4,9]]},"article-number":"20200354"}}