{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:23:48Z","timestamp":1780619028058,"version":"3.54.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1115","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To report our experience on stereotactic body radiotherapy (SBRT) in adrenal metastases from lung cancer. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> 37 oligometastatic lung cancer patients with 38 adrenal metastases submitted to SBRT were retrospectively analyzed. SBRT was delivered by volumetric modulated arc therapy (VMAT) or helical tomotherapy (HT). Primary study end point was local recurrence-free survival (LR-FS) and secondary end points were distant-progression free survival (d-PFS) and overall survival (OS). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Median age was 67 years and primary tumor was non-small-cell lung cancer in 27 (73%) and small-cell lung cancer in 10 (27%) patients. Adrenal metastases were in the left side in 66% cases. Median prescribed dose was 30\u2009Gy in 5 fractions for a median biologically equivalent dose (\u03b1\/\u03b2 ratio 10\u2009\u2009Gy, BED10) of 48\u2009Gy. Most patients (62%) were submitted to SBRT alone, while the others (38%) received chemo-, immune- or target- therapies. Median follow-up was 10.5 months, median OS 16 months and median d-PFS 3 months. 27 (70%) patients obtained a local control with a median LR-FS of 32 months. LR-FS was significantly related to BED10 with a better LC with BED10 \u226572\u2009Gy, 1- and 2\u2009year LR-FS rates were 54.1\u00b111.6% and 45\u00b112.7%\u2009vs 100 and 100% for BED \u226459.5\u2009Gy and BED \u226572\u2009Gy, respectively (p = 0.05). There was no severe toxicity. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> SBRT was effective and safe in lung cancer adrenal metastases. A dose\u2013response relationship was found between BED10 &gt;72\u2009Gy and better local control. No significant toxicity was registered thanks to the respect of dose constraints and suspension of chemo- and target-therapies. <\/jats:p><\/jats:sec><jats:sec><jats:title>Advances in knowledge:<\/jats:title><jats:p> SBRT with a BED10 &gt;72\u2009Gy is an effective treatment for adrenal oligometastatic lung cancer patients. <\/jats:p><\/jats:sec>","DOI":"10.1259\/bjr.20200645","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T23:08:36Z","timestamp":1598051316000},"page":"20200645","source":"Crossref","is-referenced-by-count":19,"title":["Stereotactic body radiotherapy for adrenal oligometastasis in lung cancer patients"],"prefix":"10.1093","volume":"93","author":[{"given":"Fabio","family":"Arcidiacono","sequence":"first","affiliation":[{"name":"Radiotherapy Oncology Centre, \u201cS. 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