{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:58:13Z","timestamp":1780599493834,"version":"3.54.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1115","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:p> Objective: <\/jats:p><jats:p> The aim of this study was to predict response to neoadjuvant chemotherapy (NAC) in patients with locally advanced hypopharyngeal cancer by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). <\/jats:p><jats:p> Methods: <\/jats:p><jats:p> A retrospective study enrolled 46 diagnosed locally advanced hypopharyngeal cancer. DCE-MRI were performed prior to and after two cycles of NAC. The volume transfer constant (K<jats:sup>trans<\/jats:sup>), extracellular extravascular volume fraction (V<jats:sub>e<\/jats:sub>), and plasma volume fraction (K<jats:sub>ep<\/jats:sub>) were computed from primary tumors. DCE-MRI parameters were used to measure tumor response according to the Response Evaluation Criteria in Solid Tumors criteria (RECIST). <\/jats:p><jats:p> Results\uff1a <\/jats:p><jats:p> After 2 NAC cycles, 30 out of 46 patients were categorized into the responder group, whereas the other 16 were categorized into non-responder group. Compared with the pretreatment value, the post-treatment K<jats:sup>trans<\/jats:sup> and K<jats:sub>ep <\/jats:sub>was significantly lower (P &lt; 0.05), but no significant change in V<jats:sub>e<\/jats:sub> (P &gt; 0.05). Compared with non-responders, a notably higher pretreatment K<jats:sup>trans<\/jats:sup>, K<jats:sub>ep<\/jats:sub>, lower post-treatment K<jats:sup>trans<\/jats:sup>, higher \u0394K<jats:sup>trans<\/jats:sup> and \u0394K<jats:sub>ep<\/jats:sub> were observed in responders (all P &lt; 0.05). While the pretreatment V<jats:sub>e<\/jats:sub>, post-treatment V<jats:sub>e<\/jats:sub>, and \u0394V<jats:sub>e<\/jats:sub> did not differ significantly (P&gt;0.05) between the two groups. The receiver operating characteristic curve analysis revealed that pretreatment K<jats:sup>trans<\/jats:sup> of 0.202\/min is the most optimal cut-off in predicting response to chemotherapy, resulting in an AUC of 0.837 and corresponding sensitivity and specificity of 76.7%, and 81.1%, respectively. <\/jats:p><jats:p> Conclusion: <\/jats:p><jats:p> DCE-MRI especially pretreatment K<jats:sup>trans<\/jats:sup> can potentially predict the treatment response to neoadjuvant chemotherapy for hypopharyngeal cancer. <\/jats:p><jats:p> Advances in knowledge: <\/jats:p><jats:p> Few studies of DCE-MRI on hypopharyngeal cancer treated with chemoradiation reported. The results demonstrate that DCE-MRI especially pretreatment K<jats:sup>trans<\/jats:sup> may be more potential value in predicting the treatment response to neoadjuvant chemotherapy for hypopharyngeal cancer. <\/jats:p>","DOI":"10.1259\/bjr.20200751","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T19:18:31Z","timestamp":1599851911000},"page":"20200751","source":"Crossref","is-referenced-by-count":7,"title":["Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for pretreatment prediction of neoadjuvant chemotherapy response in locally advanced hypopharyngeal cancer"],"prefix":"10.1093","volume":"93","author":[{"given":"Wei","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Radiology, Peking University Third Hospital, Beijing, 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huishu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Peking University Third Hospital, Beijing, 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24651"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21613"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.6309"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70011-1"},{"key":"b5","first-page":"2091","volume":"349","author":"Forastiere AA","year":"2003","journal-title":"et a1.Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. 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