{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:09:32Z","timestamp":1784887772809,"version":"3.55.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1119","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>(a) To comparatively evaluate the performance of grayscale ultrasound features, power Doppler (PD) blood flow characteristics, and gel infusion sonography (GIS) in diagnosing endometrial cancer during real-time examination, (b) to compare the performance of real-time diagnosis of endometrial cancer by experienced observers with offline analysis by blinded observers using similar sonographic criteria during review of cine loop clips.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>152 females with post-menopausal bleeding (PMB) had ET \u2265 4\u2009mm at first-line ultrasound were included. Two experienced radiologists evaluated endometrial patterns at real-time evaluation (grayscale ultrasound, PD, and GIS), then examinations were stored as video clips for later evaluation by two less-experienced radiologists. The reference standard was hysteroscopy (HY) and\/or hysterectomy with the histopathological examination. The area under (AUC) the receiver operating characteristic (ROC) curve was calculated to assess the diagnostic performance for the prediction of endometrial cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Among 152 females with ET \u2265 4\u2009mm at first line TVUS, 88 (57.9%) patients had endometrial cancer on final pathologic analysis. Real-time ultrasound criteria (ET \u2265 5\u2009mm with the presence of irregular branching endometrial blood vessels or multiple vessels crossing EM or areas with densely packed color-splash vessels with non-intact or interrupted EMJ at the grayscale ultrasound and\/or GIS) correctly diagnosed 95% of endometrial cancers with 92% diagnostic efficiency.<\/jats:p>\n                  <jats:p>There is comparable accuracy of real-time evaluation (96%) and offline analysis (92%) after the exclusion of poor quality videos from the analysis. The diagnostic criteria showed good to an excellent agreement between real-time ultrasound and offline analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>When real-time ultrasound is performed with good technique, utilizing multiple parameters, it is possible to diagnose endometrial cancer with a high degree of accuracy and reproducibility.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>when real-time ultrasound is performed with good technique, utilizing multiple parameters, it is possible to diagnose endometrial cancer with a high degree of accuracy and reproducibility.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20201195","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T21:18:20Z","timestamp":1612300700000},"source":"Crossref","is-referenced-by-count":3,"title":["Multiparametric transvaginal ultrasound in the diagnosis of endometrial cancer in post-menopausal bleeding: diagnostic performance of a transvaginal algorithm and reproducibility amongst less experienced observers"],"prefix":"10.1093","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0908-8865","authenticated-orcid":false,"given":"Shimaa","family":"Abdalla","sequence":"first","affiliation":[{"name":"South Egypt Cancer Institute, Assiut University, Egypt , Asyut , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham","family":"Abou-Taleb","sequence":"additional","affiliation":[{"name":"Women Health Hospital, Assiut University, Egypt , Asyut , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia M.","family":"Badary","sequence":"additional","affiliation":[{"name":"Department of Pathology, Assiut University , Assiut , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wageeh A.","family":"Ali","sequence":"additional","affiliation":[{"name":"Radiodiagnosis Department, Faculty of Medicine, Assiut University , Asyut , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"2024050215254444800_b1","unstructured":"NCCN Clinical Practice Guidelines in Oncology: uterine Cancer\n.. ;\n2018\n\u00a0Available\n\u00a0NCCN\n. 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