{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:47:11Z","timestamp":1790246831802,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1130","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To determine the impact of Human Papilloma Virus (HPV) oropharyngeal cancer (OPC) status on the prediction of head and neck squamous cell cancer (HNSCC) chemoradiotherapy (CRT) outcomes with pre-treatment quantitative diffusion-weighted magnetic resonance imaging (DW-MRI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Following ethical approval, 65 participants (53 male, age 59.9 \u00b1 7.86) underwent pre-treatment DW-MRI in this prospective cohort observational study. There were 46 HPV OPC and 19 other HNSCC cases with Stage III\/IV HNSCC. Regions of interest (ROIs) (volume, largest area, core) at the primary tumour (n = 57) and largest pathological node (n = 59) were placed to analyse ADCmean and ADCmin. Unpaired t-test or Mann\u2013Whitney test evaluated the impact of HPV OPC status and clinical parameters on their prediction of post-CRT 2\u2009year locoregional and disease-free survival (LRFS and DFS). Multivariate logistic regression compared significant variables with 2\u2009year outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>On univariate analysis of all participants, the primary tumour area ADCmean was predictive of 2\u2009year LRFS (p = 0.04). However, only the HPV OPC diagnosis (LFRS p = 0.03; DFS p = 0.02) predicted outcomes on multivariate analysis. None of the pre-treatment ADC values were predictive of 2\u2009year DFS in the HPV OPC subgroup (p = 0.21\u20130.68). Amongst participants without 2\u2009year disease-free survival, HPV-OPC was found to have much lower primary tumour ADCmean values than other HNSCC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Knowledge of HPV OPC status is required in order to determine the impact of the pre-treatment ADC values on post-CRT outcomes in HNSCC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>Pre-treatment ADCmean and ADCmin values acquired using different ROI methods are not predictive of 2\u2009year survival outcomes in HPV OPC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20210333","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T07:32:01Z","timestamp":1623396721000},"source":"Crossref","is-referenced-by-count":6,"title":["The impact 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Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Burd","sequence":"additional","affiliation":[{"name":"Department of Radiology, Guy\u2019s Hospital , London , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Guha","sequence":"additional","affiliation":[{"name":"Department of Radio-diagnosis, Tata Memorial Hospital, Parel, Homi Bhabha National Institute , Mumbai , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Oncology, Guy\u2019s Hospital , London , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Guerrero-Urbano","sequence":"additional","affiliation":[{"name":"Department of Oncology, Guy\u2019s Hospital , London , United 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