{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:26:56Z","timestamp":1791437216268,"version":"4.3.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1130","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>Single prolonged breath-holds of &amp;gt;5 min can be obtained in cancer patients. Currently, however, the preparation time in each radiotherapy session is a practical limitation for clinical adoption of this new technique. Here, we show by how much our original preparation time can be shortened without unduly compromising breath-hold duration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>44 healthy subjects performed single prolonged breath-holds from 60% O2 and mechanically induced hypocapnia. We tested the effect on breath-hold duration of shortening preparation time (the durations of acclimatization, hyperventilation and hypocapnia) by changing these durations and or ventilator settings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Mean original breath-hold duration was 6.5 \u00b1 0.2 (standard error) min. The total original preparation time (from connecting the facemask to the start of the breath-hold) was 26 \u00b1 1\u2009min. After shortening the hypocapnia duration from 16 to 5\u2009min, mean breath-hold duration was still 6.1 \u00b1 0.2\u2009min (ns vs the original). After abolishing the acclimatization and shortening the hypocapnia to 1\u2009min (a total preparation time now of 9 \u00b1 1\u2009min), a mean breath-hold duration of &amp;gt;5\u2009min was still possible (now significantly shortened to 5.2 \u00b1 0.6\u2009min, p &amp;lt; 0.001). After shorter and more vigorous hyperventilation (lasting 2.7 \u00b1 0.3\u2009min) and shorter hypocapnia (lasting 43 \u00b1 4\u2009s), a mean breath-hold duration of &amp;gt;5\u2009min (5.3 \u00b1 0.2\u2009min, p &amp;lt; 0.05) was still possible. Here, the final total preparation time was 3.5 \u00b1 0.3\u2009min.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>These improvements may facilitate adoption of the single prolonged breath-hold for a range of thoracic and abdominal radiotherapies especially involving hypofractionation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>Multiple short breath-holds improve radiotherapy for thoracic and abdominal cancers. Further improvement may occur by adopting the single prolonged breath-hold of &amp;gt;5\u2009min. One limitation to clinical adoption is its long preparation time. We show here how to reduce the mean preparation time from 26 to 3.5\u2009min without compromising breath-hold duration<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20210408","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T08:56:43Z","timestamp":1640077003000},"source":"Crossref","is-referenced-by-count":8,"title":["Shortening the preparation time of the single prolonged breath-hold for radiotherapy sessions"],"prefix":"10.1093","volume":"95","author":[{"given":"Michael John","family":"Parkes","sequence":"first","affiliation":[{"name":"School of Sport, Exercise & Rehabilitation Sciences, University of Birmingham , Birmingham , United Kingdom"},{"name":"National Institute for Health Research (NIHR)\/Wellcome Trust Birmingham Clinical Research Facility , Birmingham , United Kingdom"},{"name":"Hall Edwards Radiotherapy Group, University Hospitals Birmingham NHS Foundation Trust , Birmingham , United Kingdom"},{"name":"Marie Sklodowska-Curie Fellow, Department of Radiation Oncology, University Medical Centre , Amsterdam , Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Green","sequence":"additional","affiliation":[{"name":"Hall Edwards Radiotherapy Group, University Hospitals Birmingham NHS Foundation Trust , Birmingham , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Cashmore","sequence":"additional","affiliation":[{"name":"Hall Edwards Radiotherapy Group, University Hospitals Birmingham NHS Foundation Trust , Birmingham , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qamar","family":"Ghafoor","sequence":"additional","affiliation":[{"name":"Hall Edwards Radiotherapy Group, University Hospitals Birmingham NHS Foundation Trust , Birmingham , United 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