{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:44:54Z","timestamp":1768437894284,"version":"3.49.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1125","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>To assess the feasibility of a rapid, focused ferumoxytol-enhanced MR angiography (f-FEMRA) protocol in patients with claustrophobia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>In this retrospective study, 13 patients with claustrophobia expressed reluctance to undergo conventional MR angiography, but agreed to a trial of up to 10\u2009min in the scanner bore and underwent f-FEMRA. Thirteen matched control patients who underwent gadolinium-enhanced MR angiography (GEMRA) were identified for comparison of diagnostic image quality. For f-FEMRA, the time from localizer image acquisition to completion of the angiographic acquisition was measured. Two radiologists independently scored images on both f-FEMRA and GEMRA for arterial and venous image quality, motion artefact and diagnostic confidence using a 5-point scale, five being best. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in the aorta and IVC were measured. The Wilcoxon rank-sum test, one-way ANOVA with Tukey correction and two-tailed t tests were utilized for statistical analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>All scans were diagnostic and assessed with high confidence (scores \u2265 4). Average scan time for f-FEMRA was 6.27\u2009min (range 3.56 to 10.12\u2009min), with no significant difference between f-FEMRA and GEMRA in diagnostic confidence (4.86 \u00b1 0.24 vs 4.69 \u00b1 0.25, p = 0.13), arterial image quality (4.62 \u00b1 0.57 vs 4.65 \u00b1 0.49, p = 0.78) and motion artefact score (4.58 \u00b1 0.49 vs 4.58 \u00b1 0.28, p &amp;gt; 0.99). f-FEMRA scored significantly better for venous image quality than GEMRA (4.62 \u00b1 0.42 vs 4.19 \u00b1 0.56, p = 0.04). CNR in the IVC was significantly higher for steady-state f-FEMRA than GEMRA regardless of the enhancement phase (p &amp;lt; 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Comprehensive vascular MR imaging of the thorax, abdomen and pelvis can be completed in as little as 5\u2009min within the magnet bore using f-FEMRA, facilitating acceptance by patients with claustrophobia and streamlining workflow.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>A focused approach to vascular imaging with ferumoxytol can be performed in patients with claustrophobia, limiting time in the magnet bore to 10\u2009min or less, while acquiring fully diagnostic images of the thorax, abdomen and pelvis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20210430","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T14:59:17Z","timestamp":1629471557000},"source":"Crossref","is-referenced-by-count":4,"title":["Minimizing table time in patients with claustrophobia using focused ferumoxytol-enhanced MR angiography (<i>f<\/i>-FEMRA): a feasibility study"],"prefix":"10.1093","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8554-2794","authenticated-orcid":false,"given":"Puja","family":"Shahrouki","sequence":"first","affiliation":[{"name":"Department of Radiological Sciences, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System , Los Angeles, California , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim-Lien","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System , Los Angeles, California , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Moriarty","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System , Los Angeles, California , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam N.","family":"Plotnik","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System , Los Angeles, California , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takegawa","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System , Los Angeles, California , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Paul","family":"Finn","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System , Los Angeles, California , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"2024050215230617000_b1","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/jmri.21147","article-title":"Claustrophobia during magnetic resonance imaging: cohort study in over 55,000 patients","volume":"26","author":"Dewey","year":"2007","journal-title":"J Magn Reson Imaging"},{"key":"2024050215230617000_b2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00062-011-0075-4","article-title":"Wide, short bore magnetic resonance at 1.5 T: reducing the failure rate in claustrophobic patients","volume":"21","author":"Hunt","year":"2011","journal-title":"Clin Neuroradiol"},{"key":"2024050215230617000_b3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s11547-008-0358-2","article-title":"Contrast-Enhanced breast MR imaging of claustrophobic or oversized patients using an open low-field magnet","volume":"114","author":"Calabrese","year":"2009","journal-title":"Radiol Med"},{"key":"2024050215230617000_b4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/ehjci\/jes125","article-title":"Single-Centre survey of the application of cardiovascular magnetic resonance in clinical routine","volume":"14","author":"von Knobelsdorff-Brenkenhoff","year":"2013","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2024050215230617000_b5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/10976640009148683","article-title":"Treatment of claustrophobia for cardiovascular magnetic resonance: use and effectiveness of mild sedation","volume":"2","author":"Francis","year":"2000","journal-title":"J Cardiovasc Magn 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angiography for vascular access mapping before transcatheter aortic valve replacement in patients with renal impairment: a step toward patient-specific care","volume":"286","author":"Nguyen","year":"2018","journal-title":"Radiology"},{"key":"2024050215230617000_b13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ijcard.2016.12.147","article-title":"Ferumoxytol MRA for transcatheter aortic valve replacement planning with renal insufficiency","volume":"231","author":"Kallianos","year":"2017","journal-title":"Int J Cardiol"},{"key":"2024050215230617000_b14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/jmri.1880070132","article-title":"Mr angiography with an ultrasmall superparamagnetic iron oxide blood pool agent","volume":"7","author":"Anzai","year":"1997","journal-title":"J Magn Reson Imaging"},{"key":"2024050215230617000_b15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/TP.0b013e318295464c","article-title":"Renal transplant imaging using magnetic resonance angiography with a nonnephrotoxic contrast agent","volume":"96","author":"Bashir","year":"2013","journal-title":"Transplantation"},{"key":"2024050215230617000_b16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/jmri.24330","article-title":"Retrospective assessment of the utility of an iron-based agent for contrast-enhanced magnetic resonance venography in patients with endstage renal diseases","volume":"40","author":"Bashir","year":"2014","journal-title":"J Magn Reson Imaging"},{"key":"2024050215230617000_b17","doi-asserted-by":"crossref","first-page":"W366","DOI":"10.2214\/AJR.15.14534","article-title":"Vascular imaging with Ferumoxytol as a contrast agent","volume":"205","author":"Hope","year":"2015","journal-title":"AJR Am J Roentgenol"},{"key":"2024050215230617000_b18","doi-asserted-by":"crossref","DOI":"10.1016\/j.crad.2018.02.021","article-title":"Ferumoxytol-enhanced MRI in the peripheral 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Available from:\nhttps:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/022180s009lbl.pdf\n."},{"key":"2024050215230617000_b27","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/jmri.27405","article-title":"Safety of off-label use of Ferumoxtyol as a contrast agent for MRI: a systematic review and meta-analysis of adverse events","volume":"53","author":"Ahmad","year":"2021","journal-title":"J Magn Reson Imaging"},{"key":"2024050215230617000_b28","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1148\/radiol.2019190477","article-title":"Multicenter safety and practice for off-label diagnostic use of Ferumoxytol in MRI","volume":"293","author":"Nguyen","year":"2019","journal-title":"Radiology"},{"key":"2024050215230617000_b29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12968-019-0528-5","article-title":"High resolution, 3-dimensional Ferumoxytol-enhanced cardiovascular magnetic resonance venography in central venous occlusion","volume":"21","author":"Shahrouki","year":"2019","journal-title":"J Cardiovasc Magn Reson"}],"container-title":["The British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/94\/1125\/20210430\/57375587\/bjr.20210430.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjr\/article-pdf\/94\/1125\/20210430\/57375587\/bjr.20210430.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T16:44:22Z","timestamp":1714668262000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/doi\/10.1259\/bjr.20210430\/7451628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,20]]},"references-count":29,"journal-issue":{"issue":"1125","published-online":{"date-parts":[[2021,8,20]]},"published-print":{"date-parts":[[2021,9,1]]}},"URL":"https:\/\/doi.org\/10.1259\/bjr.20210430","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,9,1]]},"published":{"date-parts":[[2021,8,20]]},"article-number":"20210430"}}