{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:16:46Z","timestamp":1789615006792,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1128","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Studying the correlation of different lung parameters, using three-dimensional ultrasound (3D US) with fetal lung maturity (FLM) to predict the development of neonatal respiratory distress syndrome (RDS). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Three-dimensional ultrasound was done to record the fetal lung volume (FLV), fetal lung-to-liver intensity ratio (FLLIR) and the main pulmonary artery (MPA) blood flow parameters; pulsatility index (PI), resistive index (RI) and acceleration time-to-ejection time ratio (At\/Et), to 218\u2009women between 32 and 40 weeks gestational age within 24\u2009h from labor. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Of 218 fetuses examined, final analysis was done for 143 fetuses. Thirty eight (26.5%) were diagnosed with RDS. The MPA PI and RI were significantly higher in fetuses diagnosed with RDS compared with those without (2.51 \u00b1 0.33\u2009and 0.90 \u00b1 0.03 cm\/s versus 1.96 \u00b1 0.20\u2009and 0.84 \u00b1 0.01 cm\/s; p value &lt; 0.001\u2009and &lt;0.001 respectively). MPA At\/Et was significantly lower (0.24 \u00b1 0.04 vs 0.35 \u00b1 0.04; p value &lt; 0.001). FLLIR was significantly lower (1.04 \u00b1 0.07 vs 1.18 \u00b1 0.11; p value &lt; 0.001), and the mean FLV was significantly smaller (28.23 \u00b1 5.63, vs 38.87 \u00b1 4.68\u2009cm<jats:sup>3<\/jats:sup>; p value &lt; 0.001). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Main pulmonary artery (PI, RI, At\/Et ratio), FLIIR, and mean FLV can be used as reliable predictors of neonatal RDS. <\/jats:p><\/jats:sec><jats:sec><jats:title>Advances in knowledge:<\/jats:title><jats:p> 3D ultrasound VOCAL technique, ultrasound tissue histogram and pulmonary artery Doppler are reliable tools for prenatal prediction of fetal lung maturity. <\/jats:p><\/jats:sec>","DOI":"10.1259\/bjr.20210577","type":"journal-article","created":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T23:08:57Z","timestamp":1632092937000},"source":"Crossref","is-referenced-by-count":17,"title":["Prenatal prediction of respiratory distress syndrome by multimodality approach using 3D lung ultrasound, lung-to-liver intensity ratio tissue histogram and pulmonary artery Doppler assessment of fetal lung maturity"],"prefix":"10.1093","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-8137","authenticated-orcid":false,"given":"Yasmin Essameldin abdalla","family":"Khalifa","sequence":"first","affiliation":[{"name":"Radiology department, Women imaging unit, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona M","family":"Aboulghar","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha T","family":"Hamed","sequence":"additional","affiliation":[{"name":"Radiology department, Women imaging unit, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania H","family":"Tomerak","sequence":"additional","affiliation":[{"name":"Neonatal ICU, Cairo University, 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