{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:13:45Z","timestamp":1754558025240,"version":"3.41.2"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1127","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To evaluate the role of axillary ultrasonography (axUS) and ultrasound-guided pre-operative wire localisation of pre-treatment positive clipped node (CN) for prediction of nodal response to neoadjuvant chemotherapy (NACT) in node positive breast carcinoma patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials:<\/jats:title><jats:p> A prospective study was conducted between June 2018 and August 2020 after Ethics Committee approval. Breast carcinoma patients (cT1-cT4b) with palpable axillary nodes (cN1-cN3) and suitable for NACT were recruited after written informed consent. Single, most suspicious node was biopsied and clipped. Nodal response to NACT was assessed on axUS. Wire localisation of CN was performed prior to axillary lymph node dissection (ALND). Diagnostic performances of axUS and CN excision were assessed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Of the 69 patients evaluated, 32 patients (mean age, 43.5 \u00b1 11.8 years; females, 31\/32 [97%]; pre-menopausal, 18\/32 [56.3%]) with metastatic nodes who received NACT were included. Nodal pathological complete response rate was 34.4% (11\/32) overall and 70% (7\/10) in patients with \u22642 suspicious nodes on pre-NACT axUS. False-negative rates (FNRs) of axUS and CN excision were 4.8% and 28.6% respectively. Combination of post-NACT axUS and CN excision had an FNR of 4.8% overall and 0% in patients with \u22642 suspicious nodes on pre-NACT axUS. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Combination of AxUS and ultrasound-guided wire localisation of pre-treatment positive CN has high diagnostic accuracy for nodal restaging after NACT in node positive breast cancer patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Advances in knowledge:<\/jats:title><jats:p> Addition of axUS assessment to wire localisation of CN reduces its FNR for detecting residual metastasis after NACT. <\/jats:p><\/jats:sec>","DOI":"10.1259\/bjr.20210788","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T17:15:56Z","timestamp":1631034956000},"source":"Crossref","is-referenced-by-count":6,"title":["Axillary ultrasonography combined with pre-operative wire localisation of clipped node in nodal restaging after neoadjuvant chemotherapy in node positive breast cancer patients: a pilot study"],"prefix":"10.1093","volume":"94","author":[{"given":"Vishnu Prasad","family":"Pulappadi","sequence":"first","affiliation":[{"name":"Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5864-3154","authenticated-orcid":false,"given":"Shashi","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smriti","family":"Hari","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, 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