{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T18:18:57Z","timestamp":1782757137578,"version":"3.54.5"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1134","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>To compare second-look ultrasound (SL-ultrasound) with second-look digital breast tomosynthesis (SL-DBT) in the detection of additional lesions (ALs) with presurgical contrast-enhanced spectral mammography (CESM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>We retrospectively included 121\u2009women with 128 ALs from patients who underwent CESM for presurgical staging at our centre from September 2016 to December 2018. These ALs underwent SL-ultrasound and a retrospective review of DBT (SL-DBT) performed 1\u20133 weeks prior to CESM to evaluate the performance of each technique individually and in combination. ALs in CESM images were evaluated according to enhancement type (focus, mass, or non-mass), size (&amp;lt;10\u2009mm or &amp;gt;10\u2009mm) and level of suspicion (BI-RADS 2, 3, 4 or 5). Our gold-standard was post-biopsy histology, post-surgical specimen or &amp;gt;24\u2009month negative follow-up. McNemar\u2019s test was used for the statistical analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Out of the 128 ALs, an imaging correlate was found for 71 (55.5 %) with ultrasound, 79 (61.7%) with DBT, 53 (41.4 %) with DBT and ultrasound, and 97 (75.8%) with ultrasound and\/or DBT. SL-DBT demonstrated a higher detection rate vs SL-ultrasound in non-mass enhancement (NME) pattern (p: 0.0325) and ductal carcinoma in situ histological type (p: 0.0081). Adding SL-DBT improved the performance vs SL-ultrasound alone in the overall sample (p: &amp;lt;0.0001) and in every subcategory identified; adding SL-ultrasound to SL-DBT improved the detectability of ALs in the overall sample and in every category except for NME (p: 0.0833), foci (p: 0.0833) and B3 lesions (p: 0.3173).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Combined second-look imaging (SL-DBT+ SL-ultrasound) for CESM ALs is superior to SL-DBT alone and SL-ultrasound alone. In B3 lesions, NME, and foci, the analysis of a larger sample could determine whether adding SL-ultrasound to SL-DBT is necessary or not.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>Thanks to its high sensitivity, CESM is a useful tool in presurgical staging to detect the extent of the disease burden and identify ALs not detected with conventional imaging. Since CESM-guided biopsy systems are still scarcely available in clinical practice, it is necessary to look for other approaches to histologically characterize ALs detected with CESM. In our study, combined second-look imaging (SL-DBT + SL-ultrasound) showed better performance in terms of detectability of ALs, than either SL-DBT or SL-ultrasound alone, and allowed us to identify 91.2% of ALs that turned out to be malignant at final histology; for the remaining 8.8% it was still necessary to perform MRI or MRI-guided biopsy. However, this issue could be solved once CESM-guided biopsies spread in clinical practice. SL-DBT demonstrated a higher detection rate than SL-ultrasound in NME and ductal carcinoma in situ histology.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20210927","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T09:53:38Z","timestamp":1650621218000},"source":"Crossref","is-referenced-by-count":12,"title":["Comparison between second-look ultrasound and second-look digital breast tomosynthesis in the detection of additional lesions with presurgical CESM"],"prefix":"10.1093","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4243-8719","authenticated-orcid":false,"given":"Chiara","family":"Bellini","sequence":"first","affiliation":[{"name":"Diagnostic Senology Unit, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bicchierai","sequence":"additional","affiliation":[{"name":"Diagnostic Senology Unit, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Amato","sequence":"additional","affiliation":[{"name":"Diagnostic Senology Unit \u2013 Radiology Dpt., \u201cOspedale San Giovanni di Dio\u201d , Agrigento , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Savi","sequence":"additional","affiliation":[{"name":"Diagnostic Senology Unit, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"De Benedetto","sequence":"additional","affiliation":[{"name":"Diagnostic Senology Unit, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Di Naro","sequence":"additional","affiliation":[{"name":"Diagnostic Senology Unit, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Boeri","sequence":"additional","affiliation":[{"name":"Diagnostic Senology Unit, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermanno","family":"Vanzi","sequence":"additional","affiliation":[{"name":"Diagnostic Senology Unit, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Miele","sequence":"additional","affiliation":[{"name":"Department of Radiology, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Nori","sequence":"additional","affiliation":[{"name":"Diagnostic Senology Unit, Azienda Ospedaliero-Universitaria Careggi , Florence , 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