{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:37:54Z","timestamp":1790026674644,"version":"4.0.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1143","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Current ventilation and perfusion dose\u2013response studies focus on single-modalities (ventilation or perfusion) and perform pulmonary-toxicity assessment related to radiotherapy on a population-based basis. This study aims at quantitative and clinical evaluation of intrapatient differences between ventilation and perfusion dose\u2013responses among lung cancer patients treated with radiotherapy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> 20 patients enrolled on a prospective functional avoidance protocol underwent single photon emission computed tomography-CT ventilation and perfusion scans pre- and post-radiotherapy. Relative changes in pre- to post-treatment ventilation and perfusion in lung regions receiving \u226520\u2009Gy were calculated. In addition, the slopes of the linear fit to the relative ventilation and perfusion changes in regions receiving 0\u201360 Gy were calculated. A radiologist read and assigned a functional defect score to pre- and post-treatment ventilation\/perfusion scans. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> 25% of patients had a difference &gt;35% between ventilation and perfusion pre- to post-treatment changes and 20\u201330% of patients had opposite directions for ventilation and perfusion pre- to post-treatment changes. Using a semi-quantitative scale, radiologist assessment showed that 20% of patients had different pre- to post-treatment ventilation changes when compared to pre- to post-treatment perfusion changes. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Our data showed that ventilation dose\u2013response can differ from perfusion dose\u2013response for 20\u201330% of patients. Therefore, when performing thoracic dose\u2013response in cancer patients, it is insufficient to look at ventilation or perfusion alone; but rather both modes of functional imaging may be needed when predicting for clinical outcomes. <\/jats:p><\/jats:sec><jats:sec><jats:title>Advances in knowledge:<\/jats:title><jats:p> The significance of this study can be highlighted by the differences between the intrapatient dose\u2013response assessments of this analysis compared to existing population-based dose\u2013response analyses. Elucidating intrapatient ventilation and perfusion dose\u2013response differences may be valuable in predicting pulmonary toxicity in lung cancer patients post-radiotherapy. <\/jats:p><\/jats:sec>","DOI":"10.1259\/bjr.20220119","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T10:27:46Z","timestamp":1673519266000},"source":"Crossref","is-referenced-by-count":2,"title":["Is individual perfusion dose-response different than ventilation dose-response for lung cancer patients treated with radiotherapy?"],"prefix":"10.1093","volume":"96","author":[{"given":"Farnoush","family":"Forghani","sequence":"first","affiliation":[{"name":"Formerly at Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO, MO"},{"name":"Department of Radiation Oncology, Washington University School of Medicine, St. Loius, Missouri, United 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