{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:09:06Z","timestamp":1774465746416,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1141","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>The current study aimed to investigate the value of definitive-intent (chemo)radiotherapy in treating sinonasal undifferentiated carcinoma (SNUC) in a single institution.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>The medical records of 21 patients with SNUC treated with definitive-intent (chemo)radiotherapy between 2011 and 2021 in one single institution were retrospectively reviewed. We analyzed the treatment efficiency and long-term survivals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>A total of 21 patients were included in this cohort, 12 patients presented with T4 stage at diagnosis, and 6 in T1\/T2, 3 in T3 stage. Nine patients (42.9%, 9\/21) showed cervical lymph node metastases. All the patients were scheduled to receive definitive (chemo)radiotherapy and five patients had been performed surgery for residual tumor after (chemo)radiotherapy. 66.7% (14\/21) of patients had a complete response after the completion of treatment, 23.8% (5\/21) of partial response, one of stable disease, and one of progressed disease. The 3-year overall survival of the entire group were 86.2%, and the 3-year progress-free survival were 66.3%, respectively. 52.4% of the patients (11\/21) presented orbit invasion, compared with patients without orbit invasion, the patients who had orbit invasion were not found to have significantly poor 3-year overall survival (87.5% vs 83.3%, p = 0.38) and 3-year progression-free survival (75.0% vs 55.3%, p = 0.59).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Definitive-intent (chemo)radiotherapy could be the preferred treatment for patients with advanced SNUC, and salvage surgery should be performed for the lesions showing stable disease, progressed disease, or residual tumor.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>The value of definitive chemoradiotherapy in treating sinonasal undifferentiated carcinoma.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20220244","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T13:55:35Z","timestamp":1667310935000},"source":"Crossref","is-referenced-by-count":6,"title":["Definitive-intent (chemo)radiotherapy for sinonasal undifferentiated carcinoma"],"prefix":"10.1093","volume":"96","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Ear, Nose & Throat Hospital of Fudan University, 83 Fenyang Road , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Ear, Nose & Throat Hospital of Fudan University, 83 Fenyang Road , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianci","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Ear, Nose & Throat Hospital of Fudan University, 83 Fenyang Road , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Ear, Nose & Throat Hospital of Fudan University, 83 Fenyang Road , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Ear, Nose & Throat Hospital of Fudan University, 83 Fenyang Road , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"2024050216072018100_b1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/00000478-198611000-00004","article-title":"Sinonasal undifferentiated carcinoma. 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