{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:07:31Z","timestamp":1753884451030,"version":"3.41.2"},"reference-count":23,"publisher":"Oxford University Press (OUP)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Morphological features of an enlarged endolymphatic duct (ED) and sac (ES) are imaging biomarkers for genotype and hearing loss phenotype. We determine which biomarkers can be measured in a reproducible manner, facilitating further clinical prediction studies in enlarged vestibular aqueduct hearing loss. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> A rater reproducibility study. Three consultant radiologists independently measured previously reported MRI ED &amp; ES biomarkers (ED midpoint width, maximal ED diameter closest to the vestibule, ES length, ES width and presence of ES signal heterogeneity) and presence of incomplete partition Type 2 from 80 ears (T<jats:sub>2<\/jats:sub> weighted axial MRI). Interclass correlation coefficients (ICC) and Gwet\u2019s Agreement Coefficients (AC) were generated to give a measure of reproducibility for both continuous and categorical feature measures respectively. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> ES length, width and sac signal heterogeneity showed adequate reproducibility (ICC 95% confidence intervals 0.77\u20130.95, Gwet\u2019s AC for sac heterogeneity 0.64). When determining ED midpoint width, measurements from multiple raters are required for \u201cgood\u201d reliability (ICC 95%\u2009CI 0.75\u20130.89). Agreement on the presence of incomplete partition Type 2 ranged from \u201cmoderate\u201d to \u201csubstantial\u201d. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Regarding MR imaging, the opinion of multiple expert raters should be sought when determining the presence of an enlarged ED defined by midpoint width. ED midpoint, ES length, width and signal heterogeneity have adequate reproducibility to be further explored as clinical predictors for audiological phenotype. <\/jats:p><\/jats:sec><jats:sec><jats:title>Advances in knowledge:<\/jats:title><jats:p> We report which ED &amp; ES biomarkers are reproducibly measured. Researchers can confidently utilise these specific biomarkers when modelling progressive hearing loss associated with enlarged vestibular aqueduct. <\/jats:p><\/jats:sec>","DOI":"10.1259\/bjr.20220274","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T11:49:58Z","timestamp":1683719398000},"source":"Crossref","is-referenced-by-count":1,"title":["Can MRI biomarkers for hearing loss in enlarged vestibular aqueduct be measured reproducibly?"],"prefix":"10.1093","author":[{"given":"Haroon S","family":"Saeed","sequence":"first","affiliation":[{"name":"Department of Paediatric Otolaryngology, Royal Manchester Children\u2019s Hospital, Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azita","family":"Rajai","sequence":"additional","affiliation":[{"name":"Research & Innovation, Manchester University NHS Foundation Trust. Oxford Road, Manchester, UK"},{"name":"Centre of Biostatistics, Division of Population Health, University of Manchester, Oxford Road Manchester, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Dixon","sequence":"additional","affiliation":[{"name":"Academic Unit of Paediatric Radiology, Royal Manchester Children\u2019s Hospital, Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tejas","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Academic Unit of Paediatric Radiology, Royal Manchester Children\u2019s Hospital, Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain A","family":"Bruce","sequence":"additional","affiliation":[{"name":"Department of Paediatric Otolaryngology, Royal Manchester Children\u2019s Hospital, Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester, UK"},{"name":"Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, Oxford Road, Manchester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavros","family":"Stivaros","sequence":"additional","affiliation":[{"name":"Academic Unit of Paediatric Radiology, Royal Manchester Children\u2019s Hospital, Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester, UK"},{"name":"Division of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, medicine & Health, The University of Manchester, Oxford Road, Manchester, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00596549"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1978.88.5.723"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1080\/21695717.2016.1209002"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-021-01387-z"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.5152\/tao.2020.5864"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05279-x"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0495"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27319"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002843"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.4522"},{"volume-title":"Large Vestibular Aqueduct Syndrome: Anatomic and Functional Parameters","key":"b11"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001380"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001381"},{"journal-title":"Nhs","year":"2019","author":"Topol E","key":"b14"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200212000-00019"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"issue":"5","key":"b19","volume":"18","author":"Xie Z","year":"2018","journal-title":"Int J Simul Syst Sci Technol"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-13-61"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1972.00770090481002"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5335"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1080\/14670100.2019.1631520"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820931804"}],"container-title":["The British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.birpublications.org\/doi\/pdf\/10.1259\/bjr.20220274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T16:44:25Z","timestamp":1705077865000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/7469167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,10]]},"references-count":23,"alternative-id":["10.1259\/bjr.20220274"],"URL":"https:\/\/doi.org\/10.1259\/bjr.20220274","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"type":"print","value":"0007-1285"},{"type":"electronic","value":"1748-880X"}],"subject":[],"published":{"date-parts":[[2023,5,10]]},"article-number":"20220274"}}