{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:55:45Z","timestamp":1791996945483,"version":"4.4.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1140","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:sec><jats:title>Objectives:<\/jats:title><jats:p> To investigate the efficacy of pretreatment ADC and Ki-67 index in the prediction of the response to neoadjuvant chemotherapy (NACT) in advanced olfactory neuroblastoma (ONB) patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> A total of 21 advanced ONB patients (mean 43.48 years \u00b1 14.26; range 25\u201369 years; 13 men and 8\u2009women) with diffusion-weighted imaging (DWI) before NACT between June 2015 and October 2021 were retrospectively analyzed. Patients were categorized into responders and non-responders according to RECIST 1.1 after two cycles of NACT. The clinical data, ADC<jats:sub>mean<\/jats:sub> value, and Ki-67 index were analyzed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Kadish stage, ADC<jats:sub>mean<\/jats:sub> value, and Ki-67 index showed statistical significance between responders and non-responders. Patients with Kadish C stage were more likely to respond to platinum-based NACT (p = 0.035). Patients with the lower ADC<jats:sub>mean<\/jats:sub> value showed response to NACT (p = 0.002) and the cutoff point was 1.04 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s. Patients with the higher Ki-67 index showed response to NACT (p = 0.003) and the cutoff point was 17.5%. Predictive performance of Ki-67 index and ADC<jats:sub>mean<\/jats:sub> value showed no significance between responders and non-responders (p = 0.865). A significant negative correlation was found between ADC<jats:sub>mean<\/jats:sub> value and Ki-67 index (r = \u22120.539, p = 0.038). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> The pretreatment ADC<jats:sub>mean<\/jats:sub> value, Ki-67 index and Kadish stage have the potential to predict the response to NACT in advanced ONB patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Advances in knowledge:<\/jats:title><jats:p> This is the first study that investigated the feasibility of DWI in predicting the response to NACT in ONB patients and showed that Kadish stage, pretreatment ADC<jats:sub>mean<\/jats:sub> and Ki-67 index may play an important role in the prediction. <\/jats:p><\/jats:sec>","DOI":"10.1259\/bjr.20220367","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T19:06:40Z","timestamp":1665774400000},"source":"Crossref","is-referenced-by-count":6,"title":["The role of ADC value and Ki-67 index in predicting the response to neoadjuvant chemotherapy in advanced stages of olfactory neuroblastoma"],"prefix":"10.1093","volume":"95","author":[{"given":"Yuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaominxiang, Dongcheng District, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaominxiang, Dongcheng District, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaominxiang, Dongcheng District, Beijing, 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