{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T20:25:16Z","timestamp":1769891116407,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1138","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To assess the test\u2013retest reproducibility and intra\/interobserver agreement of apparent diffusion coefficient (ADC) measurements of myeloma lesions using whole body diffusion-weighted MRI (WB-DW-MRI) at 3T MRI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Following ethical approval, 11 consenting patients with relapsed multiple myeloma were prospectively recruited and underwent baseline WB-DW-MRI. For a single bed position, axial DWI was repeated after a short interval to permit test\u2013retest measurements.<\/jats:p>\n                  <jats:p>Mean ADC measurement was performed by two experienced observers. Intra- and interobserver agreement and test\u2013retest reproducibility were assessed, using coefficient of variation (CV) and interclass correlation coefficient (ICC) measures, for diffuse and focal lesions (small \u226410\u2009mm and large &amp;gt;10\u2009mm).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>47 sites of disease were outlined (23 focal, 24 diffuse) in different bed positions (pelvis = 22, thorax = 20, head and neck = 5). For all lesions, there was excellent intraobserver agreement with ICC of 0.99 (0.98\u20130.99) and COV of 5%. For interobserver agreement, ICC was 0.89 (0.8\u20130.934) and COV was 17%. There was poor interobserver agreement for diffuse disease (ICC = 0.46) and small lesions (ICC = 0.54).<\/jats:p>\n                  <jats:p>For test\u2013retest reproducibility, excellent ICC (0.916) and COV (14.5%) values for mean ADC measurements were observed. ICCs of test\u2013retest were similar between focal lesions (0.83) and diffuse infiltration (0.80), while ICCs were higher in pelvic (0.95) compared to thoracic (0.81) region and in small (0.96) compared to large (0.8) lesions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>ADC measurements of focal lesions in multiple myeloma are repeatable and reproducible, while there is more variation in ADC measurements of diffuse disease in patients with multiple myeloma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>Mean ADC measurements are repeatable and reproducible in focal lesions in multiple myeloma, while the ADC measurements of diffuse disease in multiple myeloma are more subject to variation. The evidence supports the future potential role of ADC measurements as predictive quantitative biomarker in multiple myeloma.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20220418","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T19:09:48Z","timestamp":1658516988000},"source":"Crossref","is-referenced-by-count":9,"title":["Repeatability and test\u2013retest reproducibility of mean apparent diffusion coefficient measurements of focal and diffuse disease in relapsed multiple myeloma at 3T whole body diffusion-weighted MRI (WB-DW-MRI)"],"prefix":"10.1093","volume":"95","author":[{"given":"Khalil","family":"ElGendy","sequence":"first","affiliation":[{"name":"Imperial College Healthcare NHS Trust , London , United Kingdom"},{"name":"The Department of Surgery and Cancer, Imperial College , London , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara D","family":"Barwick","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust , London , United Kingdom"},{"name":"The Department of Surgery and Cancer, Imperial College , London , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger W","family":"Auner","sequence":"additional","affiliation":[{"name":"The Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London , London , United Kingdom"},{"name":"Department of Haematology, Imperial College Healthcare NHS Trust , London , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristeidis","family":"Chaidos","sequence":"additional","affiliation":[{"name":"The Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London , London , United Kingdom"},{"name":"Department of 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