{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:59:25Z","timestamp":1792511965816,"version":"4.5.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> This study aimed to extract radiomics features (RFs) from pre-treatment CT scans in patients with acute ischemic stroke (AIS), and to establish a radiomics model to predict hemorrhagic transformation (HT) after endovascular therapy (EVT). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> A total of 105 patients who were diagnosed with AIS [with occlusion of the M1 segment of the middle cerebral artery (MCA) and\/or internal carotid artery] and received EVT were enrolled. They were randomly divided into the development cohort (n = 73) and the validation cohort (n = 32). The clinicoradiological data of all patients, including pre-treatment cranial CT without contrast enhancement, CT perfusion, and CT angiography, were obtained. The MCA territory on pre-treatment CT images was segmented to extract RFs associated with HT after EVT. Then, a CT radiomics model based on the selected RFs was constructed to predict HT after EVT. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The sensitivity, speci\ufb01city, and area under the curve of the CT radiomics model for predicting HT after EVT based on pre-treatment CT RFs was 0.806, 0.649, and 0.781 (95% confidence interval (CI): 0.675\u20130.886), respectively, in the development cohort. The sensitivity, specificity, and area under the curve in the validation cohort was 0.625, 0.875, and 0.797 (95% CI: 0.642\u20130.951), respectively. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> CT radiomics analysis is a valuable tool for predicting HT in AIS patients receiving EVT. It may guide the selection of patients in practice and improve procedural safety and effectiveness. <\/jats:p><\/jats:sec><jats:sec><jats:title>Advances in knowledge:<\/jats:title><jats:p> Identification of the importance of pre-treatment CT radiomics in the prediction of HT in AIS patients after EVT. <\/jats:p><\/jats:sec>","DOI":"10.1259\/bjr.20220439","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T09:21:20Z","timestamp":1682155280000},"source":"Crossref","is-referenced-by-count":16,"title":["Prediction of hemorrhagic transformation via pre-treatment CT radiomics in acute ischemic stroke patients receiving endovascular therapy"],"prefix":"10.1093","author":[{"given":"Xuehua","family":"Wen","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine Center, Department of Radiology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Center, Department of Radiology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First People\u2019s Hospital of Daishan, Zhoushan, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfa","family":"Chen","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Center, Department of Radiology, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahuan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Zhejiang Provincial People\u2019s Hospital, Affiliated People\u2019s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,22]]},"reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-014898"},{"key":"b2","volume":"2018","author":"Donkor ES","year":"2018","journal-title":"Stroke Res Treat"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-12-137"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25785"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015151169"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39651-y"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5889"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2008.00221.x"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1408"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.220582"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016160845"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4815-y"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2009005000034"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1002\/mp.12015"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00708"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.1016\/j.compmedimag.2019.02.006"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-019-00746-3"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21940"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2016.09.011"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1177\/1591019920926335"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014080"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018995"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00728"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25434"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.703258"}],"container-title":["The British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.birpublications.org\/doi\/pdf\/10.1259\/bjr.20220439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T16:44:57Z","timestamp":1705077897000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/7469148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,22]]},"references-count":25,"alternative-id":["10.1259\/bjr.20220439"],"URL":"https:\/\/doi.org\/10.1259\/bjr.20220439","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,22]]},"article-number":"20220439"}}