{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:25:18Z","timestamp":1784553918299,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1141","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To evaluate the value of radiomics models created based on non-contrast enhanced T \u00a01 weighted (T \u00a01W) and T \u00a02W fat-saturated (T \u00a02WFS) images for staging hepatic fibrosis (HF) and grading inflammatory activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and materials:<\/jats:title>\n                  <jats:p>Data of 280 patients with pathologically confirmed HF and 48 healthy volunteers were included. The participants were divided into the training set and the test set at the proportion of 4:1 by the random seed method. We used the Pyradiomics software to extract radiomics features, and then use the least absolute shrinkage and selection operator to select the optimal subset. Finally, we used the stochastic gradient descent classifier to build the prediction models. DeLong test was used to compare the diagnostic performance of the models. Receiver operating characteristics was used to evaluate the prediction ability of the models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>The diagnostic efficiency of the models based on T \u00a01W &amp; T \u00a02WFS images were the highest (all p &amp;lt; 0.05). When discriminating significant fibrosis (\u2265 F2), there were significant differences in the AUCs between the machine learning models based on T \u00a01W and T \u00a02WFS images (p &amp;lt; 0.05), but there were no significant differences in area under the receiver operating characteristic curves between the two models in other groups (all p &amp;gt; 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>The radiomics models built on T \u00a01W and T \u00a02WFS images are effective in assessing HF and inflammatory activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Advances in knowledge:<\/jats:title>\n                  <jats:p>Based on conventional MR sequences that are readily available in the clinic, namely unenhanced T \u00a01W and T \u00a02W images. Radiomics can be used for diagnosis and differential diagnosis of liver fibrosis staging and inflammatory activity grading.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1259\/bjr.20220512","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T10:03:59Z","timestamp":1667815439000},"source":"Crossref","is-referenced-by-count":15,"title":["Value of multimodal MRI radiomics and machine learning in predicting staging liver fibrosis and grading inflammatory activity"],"prefix":"10.1093","volume":"96","author":[{"given":"Huanhuan","family":"Wei","sequence":"first","affiliation":[{"name":"Academy of Medical Sciences, the People\u2019s Hospital of Zhengzhou University , Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehua","family":"Shao","sequence":"additional","affiliation":[{"name":"Heart Center of Zhengzhou University People\u2019s Hospital, Henan Provincial People\u2019s Hospital , Zhengzhou, Henan Province, 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