{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:35:00Z","timestamp":1771569300318,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1148","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p> The purpose of this study is to report the oncological outcome, observed toxicities and normal tissue complication probability (NTCP) calculation for pencil beam scanning (PBS) PT delivered to salivary gland tumour (SGT) patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We retrospectively reviewed 26 SGT patients treated with PBSPT (median dose, 67.5\u2009Gy(RBE)) between 2005 and 2020 at our institute. Toxicities were recorded according to CTCAEv.4.1. Overall survival (OS), local control (LC), locoregional control (LRC) and distant control (DC) were estimated. For all patients, a photon plan was re-calculated in order to assess the photon\/proton NTCP. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> With a median follow-up time of 46 months (range, 3\u2013118), 5 (19%), 2 (8%), 3 (12%) and 2 (8%) patients presented after PT with distant, local, locoregional failures and death, respectively. The estimated 4\u2009year OS, LC, LCR and DC were 90%, 90%, 87 and 77%, respectively. Grade 3 late toxicity was observed in 2 (8%) patients. The estimated 4\u2009year late high-grade (\u22653) toxicity-free survival was 78.4%. The calculated mean difference of NTCP-values after PBSPT and VMAT plans for developing Grade 2 or 3 xerostomia were 3.8 and 2.9%, respectively. For Grade 2\u20133 dysphagia, the grade corresponding percentages were 8.6 and 1.9%. Not using an up-front model-based approach to select patients for PT, only 40% of our patients met the Dutch eligibility criteria. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Our data suggest excellent oncological outcome and low late toxicity rates for patients with SGT treated with PBSPT. NTCP calculation showed a substantial risk reduction for Grade 2 or 3 xerostomia and dysphagia in some SGT patients, while for others, no clear benefit was seen with protons, suggesting that comparative planning should be performed routinely for these patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Advances in knowledge<\/jats:title><jats:p> We have reported that the clinical outcome of SGT patients treated with PT and compared IMPT to VMAT for the treatment of salivary gland tumour and have observed that protons delivered significantly less dose to organs at risks and were associated with less NTCP for xerostomia and dysphagia. Noteworthy, not using an up-front model-based approach, only 40% of our patients met the Dutch eligibility criteria. <\/jats:p><\/jats:sec>","DOI":"10.1259\/bjr.20220672","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T12:37:28Z","timestamp":1683031048000},"source":"Crossref","is-referenced-by-count":8,"title":["Clinical outcome after pencil beam scanning proton therapy and dysphagia\/xerostomia NTCP calculations of proton and photon radiotherapy delivered to patients with cancer of the major salivary glands"],"prefix":"10.1093","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1805-8978","authenticated-orcid":false,"given":"Marc Andrea","family":"Walser","sequence":"first","affiliation":[{"name":"Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, CH-5232 Villigen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, CH-5232 Villigen, Switzerland"},{"name":"Department of Radiation Oncology, lnselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Kluckert","sequence":"additional","affiliation":[{"name":"Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, CH-5232 Villigen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"K\u00f6the","sequence":"additional","affiliation":[{"name":"Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, CH-5232 Villigen, Switzerland"},{"name":"Department of Physics, ETH Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carson","family":"Tully","sequence":"additional","affiliation":[{"name":"Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, CH-5232 Villigen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Leiser","sequence":"additional","affiliation":[{"name":"Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, CH-5232 Villigen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antony John","family":"Lomax","sequence":"additional","affiliation":[{"name":"Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, CH-5232 Villigen, Switzerland"},{"name":"Department of Physics, ETH Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Bizzocchi","sequence":"additional","affiliation":[{"name":"Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, CH-5232 Villigen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes Albertus","family":"Langendijk","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien C","family":"Weber","sequence":"additional","affiliation":[{"name":"Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, CH-5232 Villigen, Switzerland"},{"name":"Department of Radiation Oncology, lnselspital, Bern University Hospital, University of Bern, Bern, Switzerland"},{"name":"Department of Radiation Oncology, University Hospital of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.08.021"},{"key":"b2","first-page":"1095","volume":"8","author":"Sun EC","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev a Publ Am Assoc Cancer Res Cosponsored by Am Soc Prev Oncol"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24984"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000566"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13952"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-018-0580-7"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.07.059"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.12.008"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2015.1071920"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.692885"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.07.022"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2019.1698764"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.05.010"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.08.009"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13894"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2021.01.024"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.07.041"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.05.015"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.08.020"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3599"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.11.023"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.042"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000386"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.03.018"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26563"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.14338\/IJPT-20-00044.1"},{"key":"b27","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817717661"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06652-5"},{"key":"b29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.12.009"},{"key":"b30","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24740"},{"key":"b31","doi-asserted-by":"publisher","DOI":"10.5606\/kbbihtisas.2014.00344"},{"key":"b32","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104752"},{"key":"b33","doi-asserted-by":"publisher","DOI":"10.14338\/IJPT-15-00005.1"},{"key":"b34","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20190601"},{"key":"b35","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28664"},{"key":"b36","doi-asserted-by":"publisher","DOI":"10.1159\/000358792"},{"key":"b37","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.05.007"},{"key":"b38","doi-asserted-by":"publisher","DOI":"10.1016\/j.zemedi.2020.09.003"},{"key":"b39","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27633"},{"key":"b40","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.08.022"}],"container-title":["The British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.birpublications.org\/doi\/pdf\/10.1259\/bjr.20220672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T16:45:19Z","timestamp":1705077919000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/7469124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":40,"journal-issue":{"issue":"1148","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1259\/bjr.20220672"],"URL":"https:\/\/doi.org\/10.1259\/bjr.20220672","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"article-number":"20220672"}}