{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:49:52Z","timestamp":1773978592969,"version":"3.50.1"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"1143","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To evaluate the impact of static magnetic field (SMF) presence on the radiation response of pancreatic cancer cells in polyurethane-based highly macro-porous scaffolds in hypoxic (1% O<jats:sub>2<\/jats:sub>) and normoxic (21% O<jats:sub>2<\/jats:sub>) conditions, towards understanding MR-guided radiotherapy, shedding light on the potential interaction phenomenon between SMF and radiation in a three-dimensional (3D) microenvironment. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Pancreatic cancer cells (PANC-1, ASPC-1) were seeded into fibronectin-coated highly porous polyethene scaffolds for biomimicry and cultured for 4 weeks in in vitro normoxia (21% O<jats:sub>2<\/jats:sub>) followed by a 2-day exposure to either in vitro hypoxia (1% O<jats:sub>2<\/jats:sub>) or maintenance in in vitro normoxia (21% O<jats:sub>2<\/jats:sub>). The samples were then irradiated with 6\u2009MV photons in the presence or absence of a 1.5 T field. Thereafter, in situ post-radiation monitoring (1 and 7 days post-irradiation treatment) took place via quantification of (i) live dead and (ii) apoptotic profiles. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> We report: (i) pancreatic ductal adenocarcinoma hypoxia-associated radioprotection, in line with our previous findings, (ii) an enhanced effect of radiation in the presence of SMFin in vitro hypoxia (1% O<jats:sub>2<\/jats:sub>) for both short- (1 day) and long-term (7 days) post -radiation analysis and (iii) an enhanced effect of radiation in the presence of SMF in in vitro normoxia (21% O<jats:sub>2<\/jats:sub>) for long-term (7 days) post-radiation analysis within a 3D pancreatic cancer model <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> With limited understanding of the potential interaction phenomenon between SMF and radiation, this 3D system allows combination evaluation for a cancer in which the role of radiotherapy is still evolving. <\/jats:p><\/jats:sec><jats:sec><jats:title>Advances in knowledge:<\/jats:title><jats:p> This study examined the use of a 3D model to investigate MR-guided radiotherapy in a hypoxic microenvironment, indicating that this could be a useful platform to further understanding of SMF influence on radiation. <\/jats:p><\/jats:sec>","DOI":"10.1259\/bjr.20220832","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T16:28:41Z","timestamp":1670430521000},"source":"Crossref","is-referenced-by-count":5,"title":["Enhanced effect of X-rays in the presence of a static magnetic field within a 3D pancreatic cancer model"],"prefix":"10.1093","volume":"96","author":[{"given":"Gabrielle","family":"Wishart","sequence":"first","affiliation":[{"name":"Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, University of Surrey, Guildford, UK"},{"name":"Department of Physics, University of 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