{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:28:54Z","timestamp":1766399334507,"version":"3.41.2"},"reference-count":26,"publisher":"Oxford University Press (OUP)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Although prostate calcification is often identified on pelvic CT images, calcification itself is usually not considered clinically significant. A recent histological study proposed an association between prostate calcification and prostate cancer occurrence. Our aim was to determine the predictive value of prostate calcifications for future prostate cancer occurrence. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We retrospectively analysed male patients (\u226550 years old) without prior prostate cancer history, who underwent unenhanced pelvic CT between April 2010 and March 2011, and followed-up until December 2021. Cox proportional hazards models were used to assess prostate cancer risk with prostate calcification (defined as a high-density area larger than 3\u2009mm with CT attenuation values \u2265 130\u2009HU), controlling for age, body mass index (BMI), hypertension and diabetes mellitus. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 636 male patients (mean age, 68 years \u00b1 9 [standard deviation]) were evaluated. At the end of follow-up, prostate cancer had been more frequently diagnosed in patients with prostate calcification than those without prostate calcification (6.5% vs \u20092.6%). Multivariate analysis revealed that prostate calcification on CT was a significant predictor of future prostate cancer occurrence (hazard ratio [HR], 2.7; 95%\u2009CI: 1.20, 5.91; p = 0.016). No statistical differences were observed in any other factors. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Prostate calcification may be a significant predictor of future prostate cancer occurrence, and may be used for risk stratification and to guide screening protocols. <\/jats:p><\/jats:sec><jats:sec><jats:title>Advances in knowledge:<\/jats:title><jats:p> Presence of prostate calcification on unenhanced CT scan was associated with increased incidence of prostate cancer occurrence on long term follow-up. <\/jats:p><\/jats:sec>","DOI":"10.1259\/bjr.20221110","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T09:30:10Z","timestamp":1682155810000},"source":"Crossref","is-referenced-by-count":1,"title":["Predictive value of prostate calcification for future cancer occurrence: a retrospective long-term follow-up cohort study"],"prefix":"10.1093","author":[{"given":"Soma","family":"Kumasaka","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"},{"name":"Radiological Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gunma University Hospital, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Kumasaka","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob A","family":"Dineen","sequence":"additional","affiliation":[{"name":"Radiological Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom"},{"name":"NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Tsushima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,4,22]]},"reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro1290"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810473106"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.4111\/icu.2018.59.3.187"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.09.026"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2020.12.028"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1987.tb00021_95A.x"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.23031"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.5195\/ijms.2014.76"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.04.008"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.11.013"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.01.040"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-1046"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346748"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2012.03101.x"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04033.x"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.067157"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027130"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2003.04232.x"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.09.020"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.17018"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05550-3"},{"key":"b23","first-page":"713","volume":"3","author":"Magura CE","year":"1979","journal-title":"Scan Electron Microsc"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990070110"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)66149-4"},{"key":"b26","unstructured":"ThePortal Site of Official Statistics of Japan. Reporton Internal Migration in Japan Annual Report on Internal Migration in Japan2019, e-Stat. 2019. Available from: https:\/\/www.e-stat.go.jp\/en\/dbview?sid=0003404083"}],"container-title":["The British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.birpublications.org\/doi\/pdf\/10.1259\/bjr.20221110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T16:45:53Z","timestamp":1705077953000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/7469210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,22]]},"references-count":26,"alternative-id":["10.1259\/bjr.20221110"],"URL":"https:\/\/doi.org\/10.1259\/bjr.20221110","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"type":"print","value":"0007-1285"},{"type":"electronic","value":"1748-880X"}],"subject":[],"published":{"date-parts":[[2023,4,22]]},"article-number":"20221110"}}