{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:36:35Z","timestamp":1789670195911,"version":"4.0.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1151","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Objectives:<\/jats:title><jats:p> To investigate relationships between histogram-based high-resolution CT (HRCT) indexes and pulmonary function tests (PFTs) in interstitial lung diseases. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Forty-nine patients having baseline and 1-year HRCT examinations and PFTs were investigated. Histogram-based HRCT indexes were calculated; strength of associations with PFTs was investigated using Pearson correlation. Patients were divided into progressive and non-progressive groups. HRCT indexes were compared between the two groups using the U-test; within each group, baseline and follow-up Wilcoxon analysis was performed. Receiver operating characteristic analysis was used for predicting disease progression. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> At baseline, moderate correlations were observed considering kurtosis and diffusion capacity of the lungs for carbon monoxide (DLCO) (r = 0.54) and skewness and DLCO (r = 0.559), whereas weak but significant correlations were observed between forced vital capacity and kurtosis (r = 0.368, p = 0.009) and forced vital capacity and skewness (r = 0.391, p = 0.005). Negative correlations were reported between HAA% and PFTs (from r = \u22120.418 up to r = \u22120.507). At follow-up correlations between quantitative indexes and PFTs were also moderate, except for high attenuation area (HAA)% \u2212700 and DLCO (r = \u22120.397). In progressive subgroup, moderate and strong correlations were found between DLCO and HRCT indexes (r = 0.595 kurtosis, r = 0.672 skewness, r=-0. 598 HAA% \u2212600 and r = \u22120.626 HAA% \u2212700). At follow-up, we observed significant differences between the two groups for kurtosis (p = 0.029), HAA% \u2212600 (p = 0.04) and HAA% \u2212700 (p = 0.02). To predict progression, ROC analysis reported sensitivity of 90.9% and specificity of 51.9% using a threshold value of \u03b4 kurtosis &lt;0.03. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> At one year, moderate correlations suggest that progression could be assessed through HRCT quantification. <\/jats:p><\/jats:sec><jats:sec><jats:title>Advances in knowledge:<\/jats:title><jats:p> This study promotes histogram-based HRCT indexes in the assessment of progressive pulmonary fibrosis. <\/jats:p><\/jats:sec>","DOI":"10.1259\/bjr.20221160","type":"journal-article","created":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T22:08:15Z","timestamp":1693778895000},"source":"Crossref","is-referenced-by-count":9,"title":["Histogram-based analysis in progressive pulmonary fibrosis: relationships between pulmonary functional tests and HRCT indexes"],"prefix":"10.1093","volume":"96","author":[{"given":"Stefano","family":"Palmucci","sequence":"first","affiliation":[{"name":"Department of Medical Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University Hospital Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Tiralongo","sequence":"additional","affiliation":[{"name":"Radiology Unit 1, University Hospital Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Galioto","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University Hospital Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Toscano","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University Hospital Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Reali","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University Hospital Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Scavone","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University Hospital Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Fazio","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University Hospital Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Ferlito","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University Hospital Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Sambataro","sequence":"additional","affiliation":[{"name":"Regional Referral Centre for Rare Lung Diseases, A. O. U. \"Policlinico G. Rodolico - San Marco\" Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"},{"name":"Rheumatology Outpatient Clinic Associated with the National Health System, Mascalucia (Catania), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Vancheri","sequence":"additional","affiliation":[{"name":"Department of Diseases of the Thorax, Ospedale GB Morgagni, Forl\u00ec, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Sciacca","sequence":"additional","affiliation":[{"name":"Regional Referral Centre for Rare Lung Diseases, A. O. U. \"Policlinico G. Rodolico - San Marco\" Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Vignigni","sequence":"additional","affiliation":[{"name":"Regional Referral Centre for Rare Lung Diseases, A. O. U. \"Policlinico G. Rodolico - San Marco\" Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Spadaro","sequence":"additional","affiliation":[{"name":"Regional Referral Centre for Rare Lung Diseases, A. O. U. \"Policlinico G. Rodolico - San Marco\" Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia Antonella","family":"Mauro","sequence":"additional","affiliation":[{"name":"Radiology Unit 1, University Hospital Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro Valerio","family":"Foti","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University Hospital Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Vancheri","sequence":"additional","affiliation":[{"name":"Regional Referral Centre for Rare Lung Diseases, A. O. U. \"Policlinico G. Rodolico - San Marco\" Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Basile","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Sciences and Advanced Technologies \u201cGF Ingrassia\u201d, University Hospital Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0100-2018"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0053-2017"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2020.1826665"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908681"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00692-2018"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0109-2019"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0076-2018"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2018-000289"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202202-0399ST"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0527-8"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1186\/s43055-020-0142-4"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1186\/s40248-018-0155-2"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1255ST"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.001"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149240"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.7.1072"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2282020274"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.01.019"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2015.11.011"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201711-2174OC"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.108852"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0073-2018"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201910-741OC"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0069-0"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01371-7"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-15-10"},{"key":"b27","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30433-2"}],"container-title":["The British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.birpublications.org\/doi\/pdf\/10.1259\/bjr.20221160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T16:45:57Z","timestamp":1705077957000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/7499019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":27,"journal-issue":{"issue":"1151","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1259\/bjr.20221160"],"URL":"https:\/\/doi.org\/10.1259\/bjr.20221160","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"article-number":"20221160"}}