{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:50:53Z","timestamp":1787021453438,"version":"build-2736575974"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1148","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This follow-up study of BreastScreen Victoria\u2019s pilot trial of digital breast tomosynthesis aimed to report interval cancer rates, screening sensitivity, and density-stratified outcomes for tomosynthesis vs mammography screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Prospective pilot trial [ACTRN-12617000947303] in Maroondah BreastScreen recruited females \u2265 40 years presenting for screening (August 2017\u2013November 2018) to DBT; concurrent screening participants who received mammography formed a comparison group. Follow-up of 24 months from screen date was used to ascertain interval cancers; automated breast density was measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There were 48 screen-detected and 9 interval cancers amongst 4908 tomosynthesis screens, and 34 screen-detected and 16 interval cancers amongst 5153 mammography screens. Interval cancer rate was 1.8\/1000 (95%CI 0.8\u20133.5) for tomosynthesis vs 3.1\/1000 (95%CI 1.8\u20135.0) for mammography (p = 0.20). Sensitivity of tomosynthesis (86.0%; 95%\u2009CI 74.2\u201393.7) was significantly higher than mammography (68.0%; 95%\u2009CI 53.3\u201380.5), p = 0.03. Cancer detection rate (CDR) of 9.8\/1000 (95%CI 7.2\u201312.9) for tomosynthesis was higher than that of 6.6\/1000 (95%CI 4.6\u20139.2) for mammography (p = 0.08); density-stratified analyses showed CDR was significantly higher for tomosynthesis than mammography (10.6\/1000 vs 3.5\/1000, p = 0.03) in high-density screens. Recall rate for tomosynthesis was significantly higher than for mammography (4.2% vs \u20093.0%, p &lt; 0.001), and this increase in recall for tomosynthesis was evident only in high-density screens (5.6% vs \u20092.9%, p &lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although interval cancer rates did not significantly differ between screened groups, sensitivity was significantly higher for tomosynthesis than mammography screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Advances in knowledge:<\/jats:title>\n                    <jats:p>In a program-embedded pilot trial, both increased cancer detection and recall rates from tomosynthesis were predominantly observed in high-density screens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1259\/bjr.20230081","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T08:17:45Z","timestamp":1684225065000},"source":"Crossref","is-referenced-by-count":7,"title":["Two-year follow-up of participants in the BreastScreen Victoria pilot trial of tomosynthesis versus mammography: breast density-stratified screening outcomes"],"prefix":"10.1093","volume":"96","author":[{"given":"Nehmat","family":"Houssami","sequence":"first","affiliation":[{"name":"The Daffodil Centre, the University of Sydney, a joint venture with Cancer Council NSW, Sydney, Australia"},{"name":"Sydney School of Public Health, Faculty of Medicine & Health, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Lockie","sequence":"additional","affiliation":[{"name":"Maroondah BreastScreen, Eastern Health, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Giles","sequence":"additional","affiliation":[{"name":"Maroondah BreastScreen, Eastern Health, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, Faculty of Medicine & Health, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Marr","sequence":"additional","affiliation":[{"name":"BreastScreen Victoria, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Luke","family":"Marinovich","sequence":"additional","affiliation":[{"name":"The Daffodil Centre, the University of Sydney, a joint venture with Cancer Council NSW, Sydney, Australia"},{"name":"Sydney School of Public Health, Faculty of Medicine & Health, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy121"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50320"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00194-2"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018172119"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34161"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30161-5"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021203936"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021204106"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.13452"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100804"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06549-2"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2018.1483243"},{"key":"b16","author":"Weigel S","year":"2022","journal-title":"Radiology"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192214647"}],"container-title":["The British Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.birpublications.org\/doi\/pdf\/10.1259\/bjr.20230081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T11:46:04Z","timestamp":1705059964000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjr\/article\/7469197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":14,"journal-issue":{"issue":"1148","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1259\/bjr.20230081"],"URL":"https:\/\/doi.org\/10.1259\/bjr.20230081","relation":{},"ISSN":["0007-1285","1748-880X"],"issn-type":[{"value":"0007-1285","type":"print"},{"value":"1748-880X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"article-number":"20230081"}}