{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:27:47Z","timestamp":1782484067333,"version":"3.54.5"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1151","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p> Microvascular invasion (MVI) is an independent risk factor for the early recurrence and poor survival of hepatocellular carcinoma (HCC). This study aims to investigate the potential clinical value of dynamic contrast-enhanced ultrasound (DCE-ultrasound)-Sonazoid in pre-operatively assessing MVI in HCC. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p> This single centre prospective study included 140 patients with histopathologically confirmed single HCC lesions. Patients were classified according to the post-operative pathological information presence of MVI: MVI+ group (n = 32) and MVI\u2013 group (n = 108). All patients underwent DCE-ultrasound within 1\u2009week before surgery. The quantitative perfusion parameters of HCC lesions, margins of HCC lesions, and distal liver parenchyma were obtained and analyzed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Clinicopathological (serum alpha-fetoprotein, Des-gamma-carboxyprothrombin, and pathological grade) and grayscale imaging features (tumor size) were significantly different between the MVI+ and MVI\u2013 groups (p &lt; 0.05). Further quantitative analysis showed that when comparing the MVI+ and MVI\u2013 groups, half-decrease time and wash-out rate of HCC lesions and peak enhancement in the arterial phase of difference between the margin area of HCC and distal liver parenchyma were significantly different (p = 0.045, p = 0.035, and p = 0.023, respectively). Combining the above three quantitative parameters, the accuracy, sensitivity, specificity, positive-predictive value, and negative-predictive value were 69.3% (97\/140), 37.8% (17\/45), 84.3% (80\/95), 53.1% (17\/32), 74.1% (80\/108), respectively. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> DCE-ultrasound with quantitative perfusion analysis has the potential to predict MVI in HCC lesions. <\/jats:p><\/jats:sec><jats:sec><jats:title>Advances in knowledge<\/jats:title><jats:p> DCE-ultrasound with quantitative perfusion analysis has the potential to predict MVI in HCC lesions. <\/jats:p><\/jats:sec>","DOI":"10.1259\/bjr.20230164","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T14:57:32Z","timestamp":1695740252000},"source":"Crossref","is-referenced-by-count":5,"title":["Dynamic contrast-enhanced ultrasonography with sonazoid predicts microvascular invasion in early-stage hepatocellular carcinoma"],"prefix":"10.1093","volume":"96","author":[{"given":"Zhe","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan City, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Yi","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan City, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan City, Hubei Province, 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