{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:50:52Z","timestamp":1787021452237,"version":"build-2736575974"},"reference-count":128,"publisher":"Oxford University Press (OUP)","issue":"1152","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cardiovascular diseases (CVD) are the leading cause of death worldwide and have an increasing impact on society. Precision medicine, in which optimal care is identified for an individual or a group of individuals rather than for the average population, might provide significant health benefits for this patient group and decrease CVD morbidity and mortality. Molecular imaging provides the opportunity to assess biological processes in individuals in addition to anatomical context provided by other imaging modalities and could prove to be essential in the implementation of precision medicine in CVD. New developments in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) systems, combined with rapid innovations in promising and specific radiopharmaceuticals, provide an impressive improvement of diagnostic accuracy and therapy evaluation. This may result in improved health outcomes in CVD patients, thereby reducing societal impact. Furthermore, recent technical advances have led to new possibilities for accurate image quantification, dynamic imaging, and quantification of radiotracer kinetics. This potentially allows for better evaluation of disease activity over time and treatment response monitoring. However, the clinical implementation of these new methods has been slow. This review describes the recent advances in molecular imaging and the clinical value of quantitative PET and SPECT in various fields in cardiovascular molecular imaging, such as atherosclerosis, myocardial perfusion and ischemia, infiltrative cardiomyopathies, systemic vascular diseases, and infectious cardiovascular diseases. Moreover, the challenges that need to be overcome to achieve clinical translation are addressed, and future directions are provided.<\/jats:p>","DOI":"10.1259\/bjr.20230704","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:25:30Z","timestamp":1696310730000},"source":"Crossref","is-referenced-by-count":9,"title":["The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine"],"prefix":"10.1093","volume":"96","author":[{"given":"Hendrea Sanne Aletta","family":"Tingen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen , Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijs D","family":"van Praagh","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen , Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter H","family":"Nienhuis","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen , Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alwin","family":"Tubben","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Centre Groningen , Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick D","family":"van Rijsewijk","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen , Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derk","family":"ten Hove","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen , Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouf A","family":"Mushari","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds , Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T Samara","family":"Martinez-Lucio","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen , Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar I","family":"Mendoza-Iba\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen , Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"van Sluis","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular 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