{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:02:53Z","timestamp":1776272573824,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR|case reports"],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:p> Surgery with or without post-operative radiotherapy is the mainstay treatment for salivary gland carcinoma (SGC); however, palliative radiotherapy or supportive observation is considered for elderly patients. An 87-year-old female who was diagnosed with SGC in the left parotid gland, with a clinical stage T4aN2bM0 Stage IVA, underwent the Radiation Therapy Oncology Group 8502 \u201cQUAD shot\u201d regimen (14.8\u2009Gy\/4 fractions, twice-daily treatment with a 6\u2009h interval, on 2 consecutive days), which were repeated every 4 weeks 3 times using volumetric modulated arc therapy. During and after the treatment, she experienced no acute toxicity but had Grade 1 xerostomia. At 4 months after completion of the treatment, [<jats:sup>18<\/jats:sup>F]-fluoro-2-deoxy-D-glucose positron emission tomography\/CT revealed a complete metabolic response to the treatment. She is still alive without any evidence of recurrence 9 months after completion of the treatment. The Radiation Therapy Oncology Group 8502 \u201cQUAD shot\u201d regimen using VMAT may be an effective palliative treatment for SGC with minimal toxicity. <\/jats:p>","DOI":"10.1259\/bjrcr.20190132","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T17:57:52Z","timestamp":1591379872000},"page":"20190132","source":"Crossref","is-referenced-by-count":1,"title":["QUAD shot: an effective cyclical hypofractionated palliative radiotherapy for salivary gland carcinoma"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9764-5718","authenticated-orcid":false,"given":"Ryo","family":"Toya","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Watakabe","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohsei","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daizo","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Mizutari","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Kumamoto Red Cross Hospital, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yorihisa","family":"Orita","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuo","family":"Oya","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.02870.x"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13952"},{"key":"b3","unstructured":"NCCN clinical practice guidelines in oncology. 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