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A 76-year-old female who suffered from cT3N0M0 keratinizing squamous cell carcinoma of the nasopharynx was treated with definitive concurrent chemoradiation therapy involving IMRT. However, physical examination and laryngoscope fibre finding showed evident residual tumour at 60\u2009Gy of IMRT, then, boost HDR-ISBT was proposed. After delivering 66\u2009Gy of IMRT, CT image-guided HDR-ISBT 4\u2009Gy in a single fraction was performed under local anaesthesia and sedation. MRI taken 5 months after HDR-ISBT showed remarkable shrinkage of the primary tumour. After HDR-ISBT, the remaining session of IMRT was delivered from the next day until 70\u2009Gy in 35 fractions. It was demonstrated that boost HDR-ISBT combined with IMRT for keratinizing squamous cell carcinoma of the nasopharynx was performed safely and showed favourable efficacy. <\/jats:p>","DOI":"10.1259\/bjrcr.20200005","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T18:53:22Z","timestamp":1598036002000},"page":"20200005","source":"Crossref","is-referenced-by-count":0,"title":["Image-guided interstitial brachytherapy boost for keratinizing squamous cell carcinoma of inferior wall of the nasopharynx"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0660-9987","authenticated-orcid":false,"given":"Naoya","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department 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