{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T00:20:24Z","timestamp":1705105224121},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR|case reports"],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:p> Increased vascular cell adhesion (hyperadhesion) to the endothelium is responsible for the hallmark acute pain episodes, or vaso-occlusive crises (VOC), of sickle cell disease. The integrin \u03b1<jats:sub>v<\/jats:sub>\u03b2<jats:sub>3<\/jats:sub> plays an important role in VOC since it mediates sickle red blood cell adhesion to the endothelium, a process that leads to ischemia and painful bone infarction. In the pilot study presented herein, we hypothesized that real-time imaging of hyperadhesion could quantify VOC severity and identify the most vulnerable anatomical sites. We also hypothesized that harnessing hyperadhesion as a proximate event in VOC would provide sensitive, objective evidence of VOC before pain has developed. Specifically, we tested whether positron emission tomography (PET) imaging of integrin \u03b1<jats:sub>v<\/jats:sub>\u03b2<jats:sub>3<\/jats:sub> using the PET tracer <jats:sup>68<\/jats:sup>Ga-PRGD2 would successfully image hyperadhesion associated with VOC in a patient with sickle cell disease. We observed persistently higher tracer uptake in the femurs during VOC compared to baseline. In the vessel, after an initial and transient increase during VOC, blood pool activity was similar between baseline and VOC. These findings suggest that PET imaging of integrin \u03b1<jats:sub>v<\/jats:sub>\u03b2<jats:sub>3<\/jats:sub> may be a valuable strategy for imaging of VOC. <\/jats:p>","DOI":"10.1259\/bjrcr.20200024","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T20:54:25Z","timestamp":1592254465000},"page":"20200024","source":"Crossref","is-referenced-by-count":0,"title":["First report of <sup>68<\/sup>Ga-PRGD2 PET\/MRI molecular imaging of vaso-occlusion in a patient with sickle cell disease"],"prefix":"10.1093","volume":"6","author":[{"given":"Enrico M","family":"Novelli","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States"},{"name":"Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Hong","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pittsburgh, Pittsburgh, PA, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany A","family":"Pham","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Foster City, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia A","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda","family":"Little-Ihrig","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Tavakoli","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States"},{"name":"Gilead Sciences, Foster City, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Scott","family":"Mason","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Foster City, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixin","family":"Lang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles M","family":"Laymon","sequence":"additional","affiliation":[{"name":"Gilead Sciences, Foster City, CA"},{"name":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark T","family":"Gladwin","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn J","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States"},{"name":"Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Radiology, University of Pittsburgh, Pittsburgh, PA, Pennsylvania"},{"name":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012418-012838"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6869"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.2.368"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0042"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01054.2006"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.6.1411.1411"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80393-0"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1021\/mp5003224"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.7150\/thno.8809"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.160648"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20160130"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2018.1.482"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.3109\/03630269509005824"}],"container-title":["BJR|case reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.birpublications.org\/doi\/pdf\/10.1259\/bjrcr.20200024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T15:49:53Z","timestamp":1705074593000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjrcr\/article\/7244060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12,1]]}},"alternative-id":["10.1259\/bjrcr.20200024"],"URL":"https:\/\/doi.org\/10.1259\/bjrcr.20200024","relation":{},"ISSN":["2055-7159"],"issn-type":[{"value":"2055-7159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,1]]}}}