{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:05:57Z","timestamp":1753884357481,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJR|case reports"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p> Composite pheochromocytoma is an extremely rare tumor that comprises a pheochromocytoma and an embryologically related neurogenic tumor, such as ganglioneuroma, ganglioneuroblastoma, neuroblastoma, or peripheral nerve sheath tumor. <\/jats:p><jats:p> A 46-year-old male with hypertension, elevated plasma catecholamine levels, and suspected pheochromocytoma presented to the National Defense Medical College Hospital. CT and MRI showed two adjacent masses in the left adrenal gland; one was a 6\u2009cm cephalic lesion and the other was a 1.5\u2009cm caudal lesion. Only the 1.5\u2009cm caudal mass showed uptake on <jats:sup>123<\/jats:sup>I-metaiodobenzylguanisine single photon emission CT\/CT. Pheochromocytoma was suspected and a left adrenalectomy was performed. Pathology confirmed that the 6\u2009cm mass was a ganglioneuroma and the 1.5\u2009cm mass a pheochromocytoma, with cellular intermingling at their border. The two masses were diagnosed as a composite pheochromocytoma\u2013ganglioneuroma. This is the first report in which the two components of a composite pheochromocytoma can be clearly distinguished in the pre-operative images. If a patient with clinically suspected pheochromocytoma has different components from a typical pheochromocytoma, composite pheochromocytoma should be considered. <\/jats:p>","DOI":"10.1259\/bjrcr.20220079","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T17:40:30Z","timestamp":1657906830000},"source":"Crossref","is-referenced-by-count":0,"title":["Composite pheochromocytoma\u2013ganglioneuroma: a case with two distinct components radiographically"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9602-2700","authenticated-orcid":false,"given":"Hiromi","family":"Edo","sequence":"first","affiliation":[{"name":"Department of Radiology, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiko","family":"Hyoue","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Morimura","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kousuke","family":"Okano","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Urology, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Urology, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiya","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Basic Pathology, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Edo","sequence":"additional","affiliation":[{"name":"Division of Behavioral Science, National Defense Medical College Research Institute, Saitama, Japan"},{"name":"Department of Clinical Research Medicine, Teikyo University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Shinmoto","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Defense Medical College, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-017-1200-x"},{"key":"b2","unstructured":"Tischler AS, Krijger RR, Kimura N, Komminoth P, Lloyd RV. WHO classification of tumours of endocrine organs. 4th edn. 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