{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:18:47Z","timestamp":1788067127160,"version":"build-2784847793"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentomaxillofacial Radiology"],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"Objective:<\/jats:title> To analyze medication-related osteonecrosis of the jaw (MRONJ) with bone single photon emission computed tomography (SPECT)\/CT, especially relationship between patient characteristics and maximum standardized uptake value (SUV). <\/jats:p><\/jats:sec>Methods:<\/jats:title> 48 patients with MRONJ who underwent bone SPECT\/CT were prospectively included. MRONJ patients were included 34 osteoporosis and 14 bone metastases from 6 lung cancer, 6 breast cancer and 2 rectal cancer. The maximum SUV of the MRONJ patient characteristics were analyzed such as gender, location, underlying disease, medication and staging of MRONJ by Mann\u2013Whitney U test. P-values lower than 0.05 indicate significant differences. <\/jats:p><\/jats:sec>Results:<\/jats:title> Regarding underlying disease, maximum SUV of patients with osteoporosis (18.69 \u00b1 8.57) were significantly higher than those with bone metastases (12.28 \u00b1 4.32, p = 0.005). Furthermore, maximum SUV of MRONJ was a significant difference for medication (denosumab: 13.62 \u00b1 5.70\u2009and minodronate: 22.98 \u00b1 11.73, p = 0.009) and staging of MRONJ (Stage 2: 15.59 \u00b1 8.06\u2009and Stage 3: 21.51 \u00b1 7.15, p = 0.014). <\/jats:p><\/jats:sec>Conclusion:<\/jats:title> Maximum SUV assessed by SPECT\/CT was significantly increased in MRONJ patients with osteoporosis and Stage 3. Bone SPECT\/CT could be an effective tool for the analysis of MRONJ. <\/jats:p><\/jats:sec>","DOI":"10.1259\/dmfr.20200516","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T19:20:52Z","timestamp":1621624852000},"source":"Crossref","is-referenced-by-count":25,"title":["Analysis of medication-related osteonecrosis of the jaw with bone SPECT\/CT: relationship between patient characteristics and maximum standardized uptake value"],"prefix":"10.1093","volume":"50","author":[{"given":"Ruri","family":"Ogawa","sequence":"first","affiliation":[{"name":"Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-8429","authenticated-orcid":false,"given":"Ichiro","family":"Ogura","sequence":"additional","affiliation":[{"name":"Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan"},{"name":"Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016152294"},{"key":"b2","first-page":"262","volume":"6","author":"Kaneta T","year":"2016","journal-title":"Am J Nucl Med Mol Imaging"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1186\/s13550-017-0300-5"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-017-1224-x"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2018.06.009"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-019-01390-5"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2019.05.025"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20200043"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-020-01485-4"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-020-00503-1"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2020.02.017"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1973-2"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2743-0"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1384-1"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2325-6"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.13127"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-019-01425-x"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.5624\/isd.2019.49.4.281"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.108917"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.12.014"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2020.07.012"}],"container-title":["Dentomaxillofacial Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.birpublications.org\/doi\/pdf\/10.1259\/dmfr.20200516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T15:55:37Z","timestamp":1705074937000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/dmfr\/article\/7261183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,12,1]]}},"alternative-id":["10.1259\/dmfr.20200516"],"URL":"https:\/\/doi.org\/10.1259\/dmfr.20200516","relation":{},"ISSN":["0250-832X","1476-542X"],"issn-type":[{"value":"0250-832X","type":"print"},{"value":"1476-542X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]},"article-number":"20200516"}}